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| Term | malignant hyperthermia | ID (Ontology) | DOID:8545 (Human Disease) |
| Definition | A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature and that has_material_basis_in heterozygous mutation in the ryanodine receptor gene (RYR1) on chromosome 19q13. Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine). | ||
| Also Known As | "anesthesia related hyperthermia" ; "malignant hyperpyrexia due to anesthesia" | ||
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autosomal genetic disease |__autosomal dominant disease__ muscular disease | |__muscle tissue disease_______| malignant hyperthermia |
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autosomal dominant disease muscle tissue disease |
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GARD:6964 ICD10CM:T88.3 ICD9CM:995.86 MESH:D008305 MIM:PS145600 NCI:C84869 ORDO:423 SNOMEDCT_US_2023_03_01:111738008 UMLS_CUI:C0024591 |
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