FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nodulus ID (Ontology) FBbt:00003680 (Fly Anatomy)
Definition Paired synaptic neuropil domain of the adult brain located just caudal to the ellipsoid body and ventral to the fan-shaped body, on either side of the midline (Hanesch et al., 1989). There are three of these structures, stacked on top of each other from dorsal to ventral, and at least two can be further divided into compartments (Wolff et al., 2015; Wolff and Rubin, 2018). There is asymmetry between the noduli, with one set always lying slightly more anterior than the other (Ito et al., 2014).[ FlyBase:FBrf0049409 FlyBase:FBrf0224194 FlyBase:FBrf0227801 FlyBase:FBrf0240744 ]
Also Known As "NO" ; "no" ; "Nod" (for all, see Synonyms field below)
Comment Ito et al. (2014) state that there are four subunits of one nodulus per hemisphere, but Wolff et al. (2015) and Wolff and Rubin (2018) class the noduli as three distinct units and count 'subunit IV' as part of nodulus 3; here we follow the Wolff nomenclature.
Links to External Ontologies
VFB:FBbt_00003680
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      17
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION      20
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       2
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN       5
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 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 nodulus (all annotations which use CV term, excluding "NOT" statements)      19      7     22    618
Spanning Tree (Parents/Children)
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multi-cell-component structure__
synaptic neuropil_______________|
                                synaptic neuropil domain
                                 |__nodulus  671 rec.
                                     |__nodulus 1 4 rec.
                                     |__nodulus 2 4 rec.
                                     |__nodulus 3 5 rec.
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Is a synaptic neuropil domain
Develops from embryonic/larval nodulus - primordial
Part of adult central complex
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Synonyms
Secondary IDs
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VFB:FBbt_00003680