FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term medulla intrinsic neuron Mi1 ID (Ontology) FBbt:00003776 (Fly Anatomy)
Definition Unicolumnar medullary intrinsic neuron with bushy, fine arborizations in medulla layers M1, M5 and M9-10 (Fischbach and Dittrich, 1989; Kind et al., 2021). The projection of this neuron branches at the inner-face of the medulla to form two to three varicose recurrent terminal specializations that extend back up to the inner border of layer M8 (Fischbach and Dittrich, 1989; Morante and Desplan, 2008). In central (non-dorsal margin) columns it receives input from an R8 photoreceptor cell, but connections are substantially weaker in dorsal margin columns (Kind et al., 2021). Pre-synaptic terminals are present mainly in medulla layers M9-M10, but also in all other layers where neurites extend laterally (Pankova and Borst, 2017). It receives input from lamina monopolar neurons L1 and L5 and centrifugal neuron C2 (Takemura et al., 2013). It outputs to T4 neurons and transmedullary neuron Tm3a (Takemura et al., 2013). It is a cholinergic neuron (Hasegawa et al., 2011; Pankova and Borst, 2017). There is usually one of these cells per optic column (Nern et al., 2025).[ FlyBase:FBrf0049410 FlyBase:FBrf0204652 FlyBase:FBrf0213020 FlyBase:FBrf0222324 FlyBase:FBrf0235353 FlyBase:FBrf0252485 FlyBase:FBrf0262545 ]
Also Known As "medullary intrinsic neuron 1" ; "medullary intrinsic neuron Mi1" ; "Mi1"
Comment Pre-synaptic terminals were assessed by labelling with a UAS-Synaptotagmin reporter (P\{UAS-HA-syt\} - FBtp0015803). The neurotransmitter was assessed by labelling cells with an anti-ChAT antibody (Hasegawa et al., 2011). The morphology of the terminals was judged from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. Connectivity and morphology in the medulla were assessed by electron microscopy reconstruction from 7 columns (Takemura et al., 2013).
Links to External Ontologies
VFB:FBbt_00003776
Annotations
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Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      29
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       3
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       3
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      14
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 Full annotation statements 
Relevant FlyBase reports
 Alleles  Genes  Insertions Constructs
 medulla intrinsic neuron Mi1 (all annotations which use CV term, excluding "NOT" statements)      32      3      4     19      6     28
     medulla intrinsic neuron Mi1 | adult stage       3       --       --       --       --       3
     medulla intrinsic neuron Mi1 | ectopic       3       --       --       --       --       2
     medulla intrinsic neuron Mi1 | larval stage       4       --       --       --       --       4
     medulla intrinsic neuron Mi1 | larval stage | somatic clone       2       --       --       --       --       2
     medulla intrinsic neuron Mi1 | P-stage       7       --       --       --       2      2
     medulla intrinsic neuron Mi1 | P-stage | somatic clone       8       --       --       --       --       6
     medulla intrinsic neuron Mi1 | pupal stage       1       --       --       --       --       --
     medulla intrinsic neuron Mi1 | pupal stage | somatic clone       1       --       --       --       --       --
     medulla intrinsic neuron Mi1 | somatic clone       5       --       --       --       1       --
Spanning Tree (Parents/Children)
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adult optic lobe columnar neuron
 |__optic lobe narrow field columnar neuron__
cholinergic neuron                           |
 |__adult cholinergic neuron_________________|
optic lobe intrinsic columnar neuron         |
 |__medulla intrinsic columnar neuron________|
adult neuron                                 |
 |__adult cholinergic neuron_________________|
secondary neuron                             |
 |__Notch ON hemilineage secondary neuron____|
Notch ON hemilineage neuron                  |
 |__Notch ON hemilineage secondary neuron____|
medulla intrinsic neuron                     |
 |__medulla intrinsic columnar neuron________|
medulla columnar neuron                      |
 |__medulla intrinsic columnar neuron________|
                                             medulla intrinsic neuron Mi1  92 rec.
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Is a medulla intrinsic columnar neuron
Notch ON hemilineage secondary neuron
adult cholinergic neuron
optic lobe narrow field columnar neuron
Develops from immature medulla intrinsic neuron Mi1
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Synonyms
  • "medullary intrinsic neuron 1" EXACT
    "medullary intrinsic neuron Mi1" EXACT
    "Mi1" EXACT VFB_SYMBOL[ FlyBase:FBrf0247762 ]
    "small field unilateral tristratified neuron" RELATED
    "Sut" RELATED
Secondary IDs
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FlyBrain_NDB:10097
VFB:FBbt_00003776