Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | medulla intrinsic neuron Mi4 | ID (Ontology) | FBbt:00003779 (Fly Anatomy) |
| Definition | Medulla intrinsic narrow field neuron with both fine and bleb-type arborizations in medulla layers M1, M2, M3 and M8, but with only fine arborizations in medulla layers M4 and M5, and only bleb-type arborizations in medulla layer M9 (Morante and Desplan, 2008; Fischbach and Dittrich, 1989). It receives input from the lamina monopolar neuron L5 and photoreceptor R8 (Takemura et al., 2013). It is a GABAergic neuron (Takemura et al., 2017). There is usually one of these cells per optic column (Nern et al., 2025).[ FlyBase:FBrf0049410 FlyBase:FBrf0204652 FlyBase:FBrf0213690 FlyBase:FBrf0222324 FlyBase:FBrf0252485 FlyBase:FBrf0262545 ] | ||
| Also Known As | "medullary intrinsic neuron Mi4" ; "Mi4" | ||
| Comment | Raghu and Borst (2011) identified this as glutamatergic using a vGlut[CNSIII]-GAL4 driver (FBti0129148), but vGlut antibody staining performed by Takemura et al. (2017) was not strong compared to neighboring cells, whereas GAD1 staining was strong. Pre- versus postsynaptic innervation judged by scoring of terminal morphology from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. Connectivity in the medulla was assessed by electron microscopy reconstruction from 7 columns (Takemura et al., 2013). Kind et al. (2020) say that it is not contacted by R7/R8 in the DRA, but not clear whether Mi4 is present in the DRA. | ||
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| VFB:FBbt_00003779 | |||
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adult optic lobe columnar neuron |__optic lobe narrow field columnar neuron__ GABAergic neuron | |__adult GABAergic neuron___________________| optic lobe intrinsic columnar neuron | |__medulla intrinsic columnar neuron________| adult neuron | |__adult GABAergic neuron___________________| secondary neuron | |__Notch OFF hemilineage secondary neuron___| Notch OFF hemilineage neuron | |__Notch OFF hemilineage secondary neuron___| medulla intrinsic neuron | |__medulla intrinsic columnar neuron________| medulla columnar neuron | |__medulla intrinsic columnar neuron________| medulla intrinsic neuron Mi4 34 rec. |
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medulla intrinsic columnar neuron Notch OFF hemilineage secondary neuron adult GABAergic neuron optic lobe narrow field columnar neuron |
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| Develops from | immature medulla intrinsic neuron Mi4 | ||
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FlyBrain_NDB:10103 VFB:FBbt_00003779 |
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