Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | transmedullary neuron Tm4 | ID (Ontology) | FBbt:00003792 (Fly Anatomy) |
| Definition | Transmedullary narrow field neuron that terminates in lobula layers 1, 2 and 4 with bleb-type arborizations, and with fine arborizations in layer 3. It displays fine arborizations in medulla layers M2, M3, M4 and M9, and has bleb-type arborizations in layers M2, M4, and M9 (Morante and Desplan, 2008; Fischbach and Dittrich, 1989). In the medulla, receives input from lamina monopolar neuron L2 and centrifugal neuron C3 (Takemura et al., 2013). In lobula layer 1, it outputs to T5 neurons (Shinomiya et al., 2014). It seems to be capable of both cholinergic and GABAergic neurotransmission. There is usually one of these cells per optic column (Nern et al., 2025).[ FlyBase:FBrf0049410 FlyBase:FBrf0204652 FlyBase:FBrf0212356 FlyBase:FBrf0220286 FlyBase:FBrf0222324 FlyBase:FBrf0225094 FlyBase:FBrf0262545 ] | ||
| Also Known As | "Tm4" | ||
| Comment | The acetylcholine neurotransmitter was assessed by co-labelling cells with a Cha-GAL4.7.4 driver (FBtp0014830) and an anti-ChAT antibody (Varija Raghu et al., 2011), and by scRNAseq detection of choline acetyltransferase (FBgn0000303) and vesicular acetylcholine transporter (FBgn0270928) expression (Davis et al., 2020). The GABA neurotransmitter was assessed by the intersection of the expression of the VGAT-GAL4 driver (FBtp0069181) and an antibody against GABA (Raghu et al., 2013). Pre- versus postsynaptic innervation judged by scoring of terminal morphology from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. Connectivity in the medulla was extrapolated from serial EM from 7 columns (Takemura et al., 2013). Connectivity in the lobula was assessed by serial section electron microscopy of a single column (Shinomiya et al., 2014). | ||
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| VFB:FBbt_00003792 | |||
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transmedullary neuron |__narrow field transmedullary neuron_____ cholinergic neuron | |__adult cholinergic neuron_______________| GABAergic neuron | |__adult GABAergic neuron_________________| adult neuron | |__adult cholinergic neuron_______________| |__adult GABAergic neuron_________________| secondary neuron | |__Notch ON hemilineage secondary neuron__| Notch ON hemilineage neuron | |__Notch ON hemilineage secondary neuron__| optic lobe narrow field columnar neuron | |__narrow field transmedullary neuron_____| transmedullary neuron Tm4 20 rec. |
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| Is a |
narrow field transmedullary neuron Notch ON hemilineage secondary neuron adult cholinergic neuron adult GABAergic neuron |
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| Develops from | immature transmedullary neuron Tm4 | ||
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FlyBrain_NDB:10155 VFB:FBbt_00003792 |
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