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General Information
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| Term |
Malpighian tubule Type I cell |
ID (Ontology) |
FBbt:00005796 (Fly Anatomy) |
| Definition |
Morphologically distinct cell type found throughout the Malpighian tubules. It is a large epithelial cell joined by septate junctions to other Type I cells, with apical microvilli and infolding of the basal membrane. There are small differences between Type I cells in different tubule segments: in the initial segment, the cells have few microvilli and are relatively narrow compared with the larger, flatter cells of the main segment. Type I cells originate from division of the ectodermal Malpighian tubules primordial cells that are found in the junction between the hindgut and midgut. Type I cell proliferation is complete by late stage 13 of embryogenesis. In the mature tubules there are on average 484 Type I cells.[ FlyBase:FBrf0064792 FlyBase:FBrf0091042 FlyBase:FBrf0108479 FlyBase:FBrf0160477 ] |
| Also Known As |
"Malpighian tubule principal cell" ; "PC" |
| Comment |
These cells are involved in primary urine production via the secretion of K+ into the lumen by a vacuolar-type H+ ATPase transporter and K+/H+ exchanger (Davies et al., 1996; Linton and O'Donnell, 1999). |
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Links to External Ontologies
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Insertions (FBti) | EXPRESSION_STAGE_TISSUE_POSITION | 9 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Alleles | Genes | Insertions | Constructs |
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Malpighian tubule Type I cell (all annotations which use CV term, excluding "NOT" statements) | 2 | 5 | 9 | 1 |
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Relationships