FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term adult lateral fan-shaped body tangential-protocerebrum neuron ExFl2 ID (Ontology) FBbt:00007535 (Fly Anatomy)
Definition GABAergic extrinsic lateral fan-shaped body tangential neuron that projects dorso-anteriorly to the posterior superior medial protocerebrum where it forms postsynaptic arborizations prior to forming presynaptic arborizations in the dorsal fan-shaped body (Young and Armstrong, 2010; Liu et al., 2016; Ni et al., 2019). The cell bodies of these neurons lie in a cluster lateral to the mushroom body calyx (Young and Armstrong, 2010). Arborization in the fan-shaped body spans a whole layer, but within that layer boundaries split the arborization into 16 segments (Young and Armstrong, 2010). These neurons express AstA-R1 and are activated downstream of glutamatergic AstA-expressing neurons, which synapse onto ExFl2 neurons in the superior medial protocerebrum, to increase daytime sleep; they also receive inhibitory input from dopaminergic neurons (Ni et al., 2019) and R2 ring neurons (Liu et al., 2016). They output onto and inhibit octopaminergic neurons in the fan-shaped body (Ni et al., 2019).[ FlyBase:FBrf0049409 FlyBase:FBrf0210154 FlyBase:FBrf0232501 FlyBase:FBrf0241449 ]
Also Known As "ExFl2" ; "F5 neuron" ; "Fl6" (for all, see Synonyms field below)
Comment 'dFB neuron' synonym added based on reference to FBrf0232501 in FBrf0241449 and paper seems to refer to a specific set rather than all neurons of dFB - https://orcid.org/0000-0002-1373-1705. Synapsing shown by GRASP and functional data (Ni et al., 2019). Dopaminergic input may be from PPL1-dFB, but not clear from Ni et al. (2019); identity of octopaminergic neurons also not clear. Fl6 mapped to ExFl2 as FlyBrain NDB (Fl6) and Young and Armstrong (2010) (ExFl2) both cite Hanesch et al. (1989) fig 22g.
Links to External Ontologies
VFB:FBbt_00007535
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Data Class Field Records
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       7
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 adult lateral fan-shaped body tangential-protocerebrum neuron ExFl2 (all annotations which use CV term, excluding "NOT" statements)       7      6
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fan-shaped body tangential neuron
 |__adult lateral fan-shaped body tangential neuron__
 |__adult dorsal fan-shaped body tangential neuron___|
interneuron                                          |
 |__input/output neuron______________________________|
GABAergic neuron                                     |
 |__adult GABAergic neuron___________________________|
adult neuron                                         |
 |__adult GABAergic neuron___________________________|
                                                     adult lateral fan-shaped body tangential-protocerebrum neuron ExFl2  13 rec.
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Is a adult lateral fan-shaped body tangential neuron
adult dorsal fan-shaped body tangential neuron
input/output neuron
adult GABAergic neuron
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FlyBrain_NDB:10272
FlyBrain_NDB:10520
VFB:FBbt_00007535