FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term dorsal organ cool cell ID (Ontology) FBbt:00047145 (Fly Anatomy)
Definition Ir21a, Ir25a and Ir93a -expressing neuron of the dorsal organ ganglion (DOG), activated by temperature decreases (Klein et al., 2015; Ni et al., 2016; Knecht et al., 2016). All three of these Ir genes are necessary for cold-induced activity of these cells (Knecht et al., 2016), with Ir21a specifying cooling, rather than warming sensitivity (Hernandez-Nunez et al., 2021). Three of these cells are found in each DOG and they are required for cold avoidance behavior (Klein et al., 2015). The sensory dendrites of these neurons exhibit membrane infoldings and lamellae in the base of the dorsal organ and they do not reach the central dome (Klein et al., 2015; Hernandez-Nunez et al., 2021). They project to an antennal lobe glomerulus posterior and slightly dorsal to the olfactory glomeruli (Klein et al., 2015; Hernandez-Nunez et al., 2021).[ FlyBase:FBrf0227329 FlyBase:FBrf0232228 FlyBase:FBrf0233685 FlyBase:FBrf0250348 ]
Also Known As "DOCC" ; "larval CC" ; "larval cooling cell" (for all, see Synonyms field below)
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VFB:FBbt_00047145
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 dorsal organ cool cell (all annotations which use CV term, excluding "NOT" statements)       2      2
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thermosensory neuron
 |__larval thermosensory neuron_____________
larval external sense organ sensory neuron  |
 |__dorsal organ sensory neuron_____________|
embryonic/larval sensory neuron             |
 |__larval thermosensory neuron_____________|
                                            dorsal organ cool cell  4 rec.
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Is a dorsal organ sensory neuron
larval thermosensory neuron
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VFB:FBbt_00047145