FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term interoceptive SEZ neuron ID (Ontology) FBbt:00048518 (Fly Anatomy)
Definition Neuron that predominantly arborizes in the subesophageal zone (SEZ) and is involved in the regulation of feeding behavior (Jourjine et al., 2016). It expresses the TRPV channel nanchung and detects decreases in osmolality (Jourjine et al., 2016). It expresses Ilp3 and has presynapses in the SEZ (Gonzalez Segarra et al., 2023). There are two of these per hemisphere (Jourjine et al., 2016).[ FlyBase:FBrf0233110 FlyBase:FBrf0257621 ]
Also Known As "interoceptive subesophageal zone neuron" ; "ISN"
Comment Two other SEZ neurons also express nan (Jourjine et al., 2016). Ilp3, but not other Ilps, required in ISNs for function in ingestion (Gonzalez Segarra et al., 2023).
Links to External Ontologies
VFB:FBbt_00048518
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Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       1
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       1
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 Alleles Insertions
 interoceptive SEZ neuron (all annotations which use CV term, excluding "NOT" statements)       1      1
     interoceptive SEZ neuron | nutrition conditional       1      1
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peptidergic neuron
 |__adult peptidergic neuron_____
neurosecretory neuron            |
 |__adult neurosecretory neuron__|
adult neuron                     |
 |__adult neurosecretory neuron__|
 |__adult peptidergic neuron_____|
                                 interoceptive SEZ neuron  2 rec.
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Is a adult neurosecretory neuron
adult peptidergic neuron
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VFB:FBbt_00048518