Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | mushroom body output neuron 3 | ID (Ontology) | FBbt:00100232 (Fly Anatomy) |
| Definition | Glutamatergic neuron whose cell body is located on the superior neuropils of each hemisphere, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber crosses the midline, and is sent ventrally towards the contralateral medial lobe, before making dendritic arborizations in the anterior and posterior layers of beta' lobe slice 2 (Aso et al., 2014). The main axon projects to the crepine and superior medial protocerebrum (SMP) on the same side, with a minor axon extending to the ipsilateral side (Aso et al., 2014). It has synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). It is also electrically synapsed by Kenyon cells via gap junctions (Liu et al., 2016). It is involved in the consolidation of long-term memory (Wu et al., 2017; Scaplen et al., 2020). There is one of these cells per hemisphere (Aso et al., 2014; Li et al., 2020). It develops from the larval MBON-e2 (Truman et al., 2023).[ FlyBase:FBrf0205263 FlyBase:FBrf0227179 FlyBase:FBrf0228212 FlyBase:FBrf0232676 FlyBase:FBrf0236302 FlyBase:FBrf0245835 FlyBase:FBrf0248215 FlyBase:FBrf0255928 ] | ||
| Also Known As | "M4beta'" ; "MB-M4" ; "MBON-03" (for all, see Synonyms field below) | ||
| Comment | Synapsing with PAM neurons determined by GRASP (Owald et al., 2015). Blocking protein synthesis in this neuron impairs normal long-term memory formation in response to negative odor-associated learning (Wu et al., 2017). GRASP was also used to show connectivity with the DAL neurons (Wu et al., 2017). | ||
| Links to External Ontologies | |||
| VFB:FBbt_00100232 | |||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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interneuron |__primary interneuron________________________ adult neuron | |__adult glutamatergic neuron_________________| primary neuron | |__primary interneuron________________________| adult mushroom body output neuron | |__adult typical mushroom body output neuron__| CNS neuron | |__supraesophageal ganglion neuron____________| adult CNS neuron | |__adult SMPad3 lineage neuron________________| glutamatergic neuron | |__adult glutamatergic neuron_________________| DAMd1 lineage neuron | |__adult SMPad3 lineage neuron________________| mushroom body output neuron 3 62 rec. |
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supraesophageal ganglion neuron adult typical mushroom body output neuron adult SMPad3 lineage neuron primary interneuron adult glutamatergic neuron |
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| Develops from | larval mushroom body output neuron e2 | ||
| Part of | adult brain | ||
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FlyBrain_NDB:10457 VFB:FBbt_00100232 |
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