FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term mushroom body output neuron 13 ID (Ontology) FBbt:00100239 (Fly Anatomy)
Definition Cholinergic neuron whose cell body is located in the dorsal-most area of the subesophageal ganglion, ventromedial to the antennal lobe of the adult brain (Tanaka et al., 2008; Aso et al., 2020). The cell body fiber ascends through the median bundle to the level of the gamma lobe before making a steep lateral turn and forming extensive axonal terminals in the crepine, superior medial protocerebrum and a few terminals in the superior intermediate protocerebrum (Tanaka et al., 2008; Aso et al., 2014). The main fiber further extends towards the vertical lobe and forms extensive dendrites in all strata of the alpha' lobe slice 2 (Tanaka et al., 2008). There is one of these cells per hemisphere (Aso et al., 2014; Li et al., 2020). It is a secondary FLAa2 (BAmas1) neuron (Truman et al., 2023). It plays an important role in retrieval of alcohol-associated memory (Scaplen et al., 2020).[ FlyBase:FBrf0205263 FlyBase:FBrf0227179 FlyBase:FBrf0245835 FlyBase:FBrf0248215 FlyBase:FBrf0255928 ]
Also Known As "MB-V4 neuron" ; "MBON-13" ; "MBON-alpha'2" (for all, see Synonyms field below)
Comment Tanaka et al. (2008) comment that there is a small possibility of interconnectedness between MB-V3 and MB-V4 because thin fibers are occasionally found connecting the two neuronal projections. Truman et al. (2023) claim two per hemisphere.
Links to External Ontologies
VFB:FBbt_00100239
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       4
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Relevant FlyBase reports
 Alleles  Insertions Constructs
 mushroom body output neuron 13 (all annotations which use CV term, excluding "NOT" statements)       2      6      4     15
Spanning Tree (Parents/Children)
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subesophageal zone neuron
 |__gnathal ganglion neuron____________________
neuron                                         |
 |__secondary neuron___________________________|
cholinergic neuron                             |
 |__adult cholinergic neuron___________________|
adult neuron                                   |
 |__adult cholinergic neuron___________________|
adult mushroom body output neuron              |
 |__adult typical mushroom body output neuron__|
adult CNS neuron                               |
 |__adult FLAa2 lineage neuron_________________|
BAmas1 lineage neuron                          |
 |__adult FLAa2 lineage neuron_________________|
                                               mushroom body output neuron 13  27 rec.
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Is a secondary neuron
adult typical mushroom body output neuron
adult FLAa2 lineage neuron
gnathal ganglion neuron
adult cholinergic neuron
Part of adult brain
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Synonyms
Secondary IDs
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FlyBrain_NDB:10464
VFB:FBbt_00100239