FB2025_05 , released December 11, 2025

General Information
Term	octopaminergic VUMd2 neuron	ID (Ontology)	FBbt:00110162 (Fly Anatomy)
Definition	Octopaminergic neuron of the VUMd cluster that exhibits a fan-shaped projection in the brain (Busch et al., 2009). Secondary neurites that originate in area surrounding the ventral esophagus foramen project to the lateral inferior posterior slope where they turn ventrally and project via the cervical connective to the ventral nerve cord (Busch et al., 2009). Projections to the posterior subesophageal ganglion and the inferior posterior slope form varicose terminals (Busch et al., 2009). It is inhibited in response to infection, and this leads to reduced egg laying in females (Masuzzo et al., 2019).[ FlyBase:FBrf0207458 FlyBase:FBrf0243879 ]
Also Known As	"OA-VUMd2" ; "pLB1+/Tdc2+ VM III neuron"
Comment	The neurotransmitter was assessed by immunostaining with an anti-octopamine (OA) antibody in cells labelled with tdc2-GAL4 (FBti0101786) and NP7088-GAL4 (FBti0037217) (Busch et al., 2009). Despite egg-laying function in females, it is present in both males and females (Masuzzo et al., 2019). DNge149 and DNge152 mapped to OA-VUMd2 (Bates et al., 2025).
Links to External Ontologies
	VFB:FBbt_00110162
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

octopaminergic VUMd2 neuron

ID (Ontology)

FBbt:00110162 (Fly Anatomy)

Definition

Octopaminergic neuron of the VUMd cluster that exhibits a fan-shaped projection in the brain (Busch et al., 2009). Secondary neurites that originate in area surrounding the ventral esophagus foramen project to the lateral inferior posterior slope where they turn ventrally and project via the cervical connective to the ventral nerve cord (Busch et al., 2009). Projections to the posterior subesophageal ganglion and the inferior posterior slope form varicose terminals (Busch et al., 2009). It is inhibited in response to infection, and this leads to reduced egg laying in females (Masuzzo et al., 2019).[ FlyBase:FBrf0207458 FlyBase:FBrf0243879 ]

Also Known As

"OA-VUMd2" ; "pLB1+/Tdc2+ VM III neuron"

Comment

The neurotransmitter was assessed by immunostaining with an anti-octopamine (OA) antibody in cells labelled with tdc2-GAL4 (FBti0101786) and NP7088-GAL4 (FBti0037217) (Busch et al., 2009). Despite egg-laying function in females, it is present in both males and females (Masuzzo et al., 2019). DNge149 and DNge152 mapped to OA-VUMd2 (Bates et al., 2025).

Links to External Ontologies

VFB:FBbt_00110162

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

descending neuron of the gnathal ganglion______ adult labial octopaminergic VM neuron__________| adult octopaminergic subesophageal VUM neuron__| octopaminergic VUMd neuron |__octopaminergic VUMd2 neuron |__descending neuron of the gnathal ganglion DNge149 |__descending neuron of the gnathal ganglion DNge152

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Relationships
Is a	octopaminergic VUMd neuron
Part of
Synonyms & Secondary IDs
Synonyms
	"OA-VUMd2" EXACT VFB_SYMBOL[ FlyBase:FBrf0207458 ] "pLB1+/Tdc2+ VM III neuron" EXACT[ FlyBase:FBrf0243879 ]
Secondary IDs

External Crossreferences & Linkouts
	VFB:FBbt_00110162

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

octopaminergic VUMd neuron

Part of

Synonyms & Secondary IDs

Synonyms

"OA-VUMd2" EXACT VFB_SYMBOL[ FlyBase:FBrf0207458 ]
"pLB1+/Tdc2+ VM III neuron" EXACT[ FlyBase:FBrf0243879 ]

Secondary IDs

External Crossreferences & Linkouts

VFB:FBbt_00110162