FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term period-positive median segmental interneuron ID (Ontology) FBbt:00111047 (Fly Anatomy)
Definition Glutamatergic, period-expressing, interneuron of the larval ventral nerve cord whose soma is located near the ventral midline of each segment (Kohsaka et al., 2014; Kohsaka et al., 2019). Its axon projects dorsally toward the dorsal midline, turns laterally and extends toward the lateral edge of the neuropil; it then makes a loop around the DL fascicle and projects back medially (Kohsaka et al., 2014; Kohsaka et al., 2019). Its terminals are mainly found in the dorsal neuropil region of the same segment as its soma (Kohsaka et al., 2014). There are around 10 of these interneurons in each hemineuromere (Kohsaka et al., 2014; Kohsaka et al., 2019), which develop from the NB2-1 neuroblast (Kohsaka et al., 2019; Mark et al., 2021).[ FlyBase:FBrf0226895 FlyBase:FBrf0242656 FlyBase:FBrf0249021 ]
Also Known As "looper neuron" ; "PMSI neuron"
Comment Kohsaka et al. (2014) and Kohsaka et al. (2019) claim there are only 10 PMSI neurons per hemineuromere (A02a-j). McNamee et al. (2016) - FBrf0232247 and Mark et al. (2021) seem to consider all lineage 2 neurons to be PMSIs (despite some lacking the characteristic dorsal loop).
Links to External Ontologies
VFB:FBbt_00111047
Annotations
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 period-positive median segmental interneuron (all annotations which use CV term, excluding "NOT" statements)       3
Spanning Tree (Parents/Children)
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larval neuron
 |__larval premotor neuron_____________
 |__larval glutamatergic neuron________|
interneuron                            |
 |__larval interneuron_________________|
NB2-1 lineage primary neuron           |
 |__lineage NB2-1 primary interneuron__|
premotor neuron                        |
 |__larval premotor neuron_____________|
primary interneuron                    |
 |__lineage NB2-1 primary interneuron__|
larval CNS neuron                      |
 |__larval interneuron_________________|
glutamatergic neuron                   |
 |__larval glutamatergic neuron________|
                                       period-positive median segmental interneuron  7 rec.
                                        |__larval A02a neuron 2 rec.
                                        |   |__larval abdominal 1 A02a neuron
                                        |   |__larval abdominal 3 A02a neuron
                                        |__larval A02b neuron 2 rec.
                                        |   |__larval abdominal 1 A02b neuron
                                        |   |__larval abdominal 2 A02b neuron
                                        |   |__larval abdominal 3 A02b neuron
                                        |__larval A02c neuron
                                        |   |__larval abdominal 1 A02c neuron
                                        |__larval A02d neuron
                                        |   |__larval abdominal 1 A02d neuron
                                        |__larval A02e neuron
                                        |   |__larval abdominal 1 A02e neuron
                                        |__larval A02f neuron
                                        |   |__larval abdominal 1 A02f neuron
                                        |__larval A02g neuron
                                        |   |__larval abdominal 1 A02g neuron
                                        |__larval A02h neuron
                                        |   |__larval abdominal 1 A02h neuron
                                        |__larval A02i neuron
                                        |   |__larval abdominal 1 A02i neuron
                                        |__larval A02j neuron
                                            |__larval abdominal 1 A02j neuron
                                            |__larval abdominal 2 A02j neuron
                                            |__larval abdominal 3 A02j neuron
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Is a lineage NB2-1 primary interneuron
larval premotor neuron
larval interneuron
larval glutamatergic neuron
Part of larval ventral nerve cord
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Synonyms
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VFB:FBbt_00111047