FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term adult CCAP protocerebrum neuron ID (Ontology) FBbt:00111317 (Fly Anatomy)
Definition Adult descending neuron that expresses Crustacean cardioactive peptide (CCAP), whose soma is located in the posterior superior medial protocerebrum cell body rind, mediolateral to the mushroom body calyx (Selcho et al., 2018; Reinhard et al., 2024). It belongs to the SMPpv1 hemilineage (Schlegel et al., 2024; Dorkenwald et al., 2024). There are two of these neurons per hemisphere, with seemingly identical innervation patterns, and they are the only CCAP cells of the central brain to survive throughout adulthood (Selcho et al., 2018). It arborizes, mainly ipsilaterally, in the superior medial protocerebrum, with pre- and postsynapses (Selcho et al., 2018; Schlegel et al., 2024; Dorkenwald et al., 2024). It follows the median bundle to innervate the flange on both sides (Selcho et al., 2018). It is involved in regulating ingestion (Gonzalez Segarra et al., 2023).[ FlyBase:FBrf0191050 FlyBase:FBrf0238423 FlyBase:FBrf0257621 FlyBase:FBrf0260535 FlyBase:FBrf0260546 FlyBase:FBrf0261099 ]
Also Known As "adult brain CCAP neuron" ; "adult CCAP-rSMPp neuron" ; "adult mCCAP neuron" (for all, see Synonyms field below)
Comment Neuron from Selcho et al. (2018) must correspond to the CCAP neuron in Gonzalez Segarra et al. (2023) as it is the only brain type that does not die and it has similar morphology. Mapped to DNpe048 in FlyWire based on reference to Gonzalez Segarra et al. (2023) in Reinhard et al. (2024) and DNpe048 is synonymous with SMP367 in FlyWire and Schlegel et al. (2024).
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VFB:FBbt_00111317
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adult neuron
 |__adult descending neuron_____________
adult neurosecretory neuron             |
 |__neurosecretory cell of adult brain__|
 |__adult CCAP neuron___________________|
CCAP neuron                             |
 |__adult CCAP neuron___________________|
neurosecretory cell of brain            |
 |__neurosecretory cell of adult brain__|
adult peptidergic neuron                |
 |__adult CCAP neuron___________________|
CNS neuron                              |
 |__supraesophageal ganglion neuron_____|
adult CNS neuron                        |
 |__adult SMPpv1 lineage neuron_________|
 |__neurosecretory cell of adult brain__|
DPMpl1 lineage neuron                   |
 |__adult SMPpv1 lineage neuron_________|
                                        adult CCAP protocerebrum neuron
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Is a supraesophageal ganglion neuron
adult descending neuron
adult SMPpv1 lineage neuron
neurosecretory cell of adult brain
adult CCAP neuron
Part of adult central nervous system
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VFB:FBbt_00111317