FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term loss of function allele ID (Ontology) FBcv:0000287 (FlyBase CV)
Definition An allele that either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type.[ FlyBase:FBrf0049147 ]
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  ALLELE_CLASS    3733
Alleles (FBal)  PROMOTED_CLASS    3398
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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 Alleles
 loss of function allele (all annotations which use CV term, excluding "NOT" statements)    3733
Spanning Tree (Parents/Children)
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  allele descriptor
   |__allele class
       |__loss of function allele  10290 rec.
           |__amorphic allele 4287 rec.
           |   |__amorphic allele - genetic evidence(+) 2018 rec.
           |   |__amorphic allele - molecular evidence(+) 2363 rec.
           |   |__temperature conditional amorphic allele(+) 8 rec.
           |__hypomorphic allele 2950 rec.
           |   |__hypomorphic allele - genetic evidence(+) 2368 rec.
           |   |__hypomorphic allele - molecular evidence(+) 605 rec.
           |   |__temperature conditional hypomorphic allele(+) 62 rec.
           |__temperature conditional loss of function allele 122 rec.
               |__cold sensitive loss of function allele(+) 11 rec.
               |__heat sensitive loss of function allele(+) 100 rec.
               |__temperature conditional amorphic allele(+) 8 rec.
               |__temperature conditional hypomorphic allele(+) 62 rec.
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