FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term ends-out gene targeting ID (Ontology) FBcv:0000711 (FlyBase CV)
Definition Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break on both sides of the homologous region in an engineered donor sequence. This double-strand break is usually generated by cutting at a single site adjacent to the homologous region in a circularized donor sequence. This typically generates a simple targeted replacement of the target sequence by the donor sequence. However, more complicated outcomes are possible.[ FlyBase:FBrf0167363 FlyBase:FBrf0202435 ]
Also Known As "change induced by ends-out gene targeting"
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Aberrations (FBab)  MUTAGEN      27
Alleles (FBal)  MUTAGEN     622
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 ends-out gene targeting (all annotations which use CV term, excluding "NOT" statements)      27    622
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  recombination
   |__gene targeting by homologous recombination
       |__ends-out gene targeting  649 rec.
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Is a gene targeting by homologous recombination
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