FB2025_05 , released December 11, 2025

CV Term Report

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General Information
Term	cold sensitive hypomorphic allele	ID (Ontology)	FBcv:0000753 (FlyBase CV)
Definition	An allele that makes a gene product that is functionally equivalent to wild-type but which at low temperatures is present in a lesser amount or with lowered activity, and that retains normal function at higher temperatures.[ FlyBase:FBrf0002371 FlyBase:FBrf0049147 ]
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Spanning Tree (Parents/Children)

hypomorphic allele
 |__temperature conditional hypomorphic allele___
temperature conditional loss of function allele  |
 |__cold sensitive loss of function allele_______|
 |__temperature conditional hypomorphic allele___|
                                                 cold sensitive hypomorphic allele  7 rec.
                                                  |__cold sensitive hypomorphic allele - genetic evidence 6 rec.
                                                  |__cold sensitive hypomorphic allele - molecular evidence 1 rec.

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Is a	cold sensitive loss of function allele temperature conditional hypomorphic allele
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