FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term CRISPR/Cas9 ID (Ontology) FBcv:0003008 (FlyBase CV)
Definition Sequence change caused by a cleavage of a specific DNA sequence induced by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 nuclease system. This system relies on the transcription of a chimeric guide RNA (gRNA) which directs the Cas9 endonuclease to a specified DNA sequence through basepairing to 20 nucleotide CRISPR target sites. These sites are located next to a 3 nucleotide protospacer adjacent motif (PAM) required for DNA cleavage.[ FlyBase:FBrf0222128 FlyBase:FBrf0222292 FlyBase:FBrf0222617 ]
Also Known As "change induced by CRISPR/Cas9 endonuclease cleavage"
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Aberrations (FBab)  MUTAGEN     240
Alleles (FBal)  MUTAGEN   17012
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Relevant FlyBase reports
 Aberrations Alleles
 CRISPR/Cas9 (all annotations which use CV term, excluding "NOT" statements)     240  17012
Spanning Tree (Parents/Children)
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  origin of mutation
   |__site specific cleavage
       |__CRISPR/Cas9  17252 rec.
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Is a site specific cleavage
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Synonyms
  • "change induced by CRISPR/Cas9 endonuclease cleavage" EXACT
    "CRISPR/Cas9 endonuclease" RELATED
Secondary IDs
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