FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nuclease ID (Ontology) FBcv:0005077 (FlyBase CV)
Definition An enzyme that catalyzes hydrolysis of DNA in a site-specific manner. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome.[ FlyBase:FBrf0231034 ]
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 Genes Experimental Tools
 nuclease (all annotations which use CV term, excluding "NOT" statements)       8      6
     encodes tool | nuclease       --       6
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  experimental tool descriptor
   |__genome engineering tool
       |__nuclease  30 rec.
           |__meganuclease 4 rec.
           |__RNA-guided nuclease 12 rec.
               |__conditional RNA-guided nuclease(+) 1 rec.
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Is a genome engineering tool
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Synonyms
  • "site-specific DNA nuclease" RELATED
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