FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term meganuclease ID (Ontology) FBcv:0007035 (FlyBase CV)
Definition An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, having a cognate recognition site of 20-30bp. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome.[ FlyBase:FBrf0231034 ]
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 meganuclease (all annotations which use CV term, excluding "NOT" statements)       2      2
     encodes tool | meganuclease       --       2
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  genome engineering tool
   |__nuclease
       |__meganuclease  4 rec.
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