FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term sickle cell disease ID (Ontology) DOID:0081445 (Human Disease)
Definition A blood protein disease that is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events that result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, resulting from the replacement of one of the beta-globin subunits in hemoglobin with atypical hemoglobin molecules called hemoglobin S which can distort red blood cells into a sickle or crescent shape. Sickle cell disease subtypes should include a detailed genotypic description for the hemoglobin molecules (e.g., Hb S/S, Hb S/C, Hb S/β0-thalassemia).
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 Genes
 sickle cell disease       1
 for disease ribbon | sickle cell disease       1
 model of | sickle cell disease       1
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  hematopoietic system disease
   |__blood protein disease
       |__sickle cell disease  1 rec.
           |__sickle cell anemia
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ICD10CM:D57
ICD9CM:282.6
MESH:D006450
MIM:603903
NCI:C34383
NCI:C34676
SNOMEDCT_US_2025_04_25:417357006
UMLS_CUI:C0019034