FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term combined immunodeficiency ID (Ontology) DOID:0111962 (Human Disease)
Definition A primary immunodeficiency disease that involves multiple components of the immune system.
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Spanning Tree (Parents/Children)
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  immune system disease
   |__primary immunodeficiency disease
       |__combined immunodeficiency  55 rec.
           |__B cell and dendritic cell deficiency 1 rec.
           |   |__immunodeficiency 59 1 rec.
           |__combined cellular and humoral immune defects with granulomas
           |__combined T cell and B cell immunodeficiency 30 rec.
           |   |__CD40 ligand deficiency
           |   |__DNA ligase IV deficiency 1 rec.
           |   |__Good syndrome
           |   |__immunodeficiency 14 1 rec.
           |   |__immunodeficiency 15A 1 rec.
           |   |__immunodeficiency 16
           |   |__immunodeficiency 23 1 rec.
           |   |__immunodeficiency 36 1 rec.
           |   |__immunodeficiency 37
           |   |__immunodeficiency 40 1 rec.
           |   |__immunodeficiency 46
           |   |__immunodeficiency 53 1 rec.
           |   |__immunodeficiency 56
           |   |__immunodeficiency 58 1 rec.
           |   |__immunodeficiency 60
           |   |__immunodeficiency 70 6 rec.
           |   |__immunodeficiency 98 8 rec.
           |   |__immunodeficiency 99 1 rec.
           |   |__immunodeficiency 120 1 rec.
           |   |__leukocyte adhesion deficiency(+) 3 rec.
           |   |__purine nucleoside phosphorylase deficiency 2 rec.
           |   |__X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia 1 rec.
           |__immunodeficiency 12
           |__immunodeficiency 33
           |__immunodeficiency 41
           |__immunodeficiency 50 1 rec.
           |__immunodeficiency 55 2 rec.
           |__immunodeficiency 71 1 rec.
           |__immunodeficiency 72 1 rec.
           |__immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis 3 rec.
           |__immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia 3 rec.
           |__immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia 3 rec.
           |__immunodeficiency 130 with HPV-related verrucosis
           |__monocyte, dendritic cell, and NK cell deficiency
           |   |__immunodeficiency 32B
           |__severe combined immunodeficiency 14 rec.
           |   |__adenosine deaminase deficiency
           |   |__CD3delta deficiency
           |   |__CD3epsilon deficiency
           |   |__CD3gamma deficiency
           |   |__CD3zeta deficiency
           |   |__CD45 deficiency
           |   |__coronin-1A deficiency 1 rec.
           |   |__immunodeficiency 11A
           |   |__immunodeficiency 15B 1 rec.
           |   |__immunodeficiency 19
           |   |__immunodeficiency 22 1 rec.
           |   |__immunodeficiency 24 1 rec.
           |   |__immunodeficiency 26 1 rec.
           |   |__immunodeficiency 121 3 rec.
           |   |__janus kinase-3 deficiency 1 rec.
           |   |__MHC class I deficiency 2 rec.
           |   |__MHC class II deficiency
           |   |__Omenn syndrome
           |   |__recombinase activating gene 1 deficiency
           |   |__recombinase activating gene 2 deficiency
           |   |__reticular dysgenesis 1 rec.
           |   |__severe combined immunodeficiency 104
           |   |__severe combined immunodeficiency 105 1 rec.
           |   |__severe combined immunodeficiency 124
           |   |__severe combined immunodeficiency with sensitivity to ionizing radiation
           |   |__severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive
           |   |__T-cell immunodeficiency, congenital alopecia, and nail dystrophy 1 rec.
           |   |__X-linked severe combined immunodeficiency
           |__T cell, B cell, and NK cell deficiency 3 rec.
               |__immunodeficiency 64
               |__immunodeficiency 112
               |__immunodeficiency 119 2 rec.
               |__immunodeficiency 122
               |__immunodeficiency 128 1 rec.
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Is a primary immunodeficiency disease
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NCI:C27871