FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term intellectual disability ID (Ontology) DOID:1059 (Human Disease)
Definition A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.
Comment
Links to External Ontologies
DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      40
Human Disease Models (FBhh)  DOID       3
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 intellectual disability      40     27      3
 ameliorates | intellectual disability       8       --       --
 exacerbates | Charcot-Marie-Tooth disease       3       --       --
 for disease ribbon | pre-eclampsia       --       3       --
 model of | Charcot-Marie-Tooth disease      19       --       --
 model of | intellectual disability      33       --       --
 model of | pre-eclampsia       --       3       --
 DOES NOT model | Charcot-Marie-Tooth disease       1       --       --
Spanning Tree (Parents/Children)
Only view relationship: 
  developmental disorder of mental health
   |__specific developmental disorder
       |__intellectual disability  756 rec.
           |__autosomal dominant intellectual developmental disorder 241 rec.
           |   |__Arboleda-Tham syndrome 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 1 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 2
           |   |__autosomal dominant intellectual developmental disorder 3 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 4
           |   |__autosomal dominant intellectual developmental disorder 5 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 6 6 rec.
           |   |__autosomal dominant intellectual developmental disorder 7 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 8 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 10 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 11 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 13 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 19 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 21 4 rec.
           |   |__autosomal dominant intellectual developmental disorder 22
           |   |__autosomal dominant intellectual developmental disorder 23 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 26 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 29
           |   |__autosomal dominant intellectual developmental disorder 30 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 31 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 33 4 rec.
           |   |__autosomal dominant intellectual developmental disorder 34 3 rec.
           |   |__autosomal dominant intellectual developmental disorder 35 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 36 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 38 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 39 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 40
           |   |__autosomal dominant intellectual developmental disorder 41 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 42 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 43 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 44 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 45 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 46 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 47 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 48 8 rec.
           |   |__autosomal dominant intellectual developmental disorder 50 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 51 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 52 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 53 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 54 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 55 4 rec.
           |   |__autosomal dominant intellectual developmental disorder 56 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 57 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 58 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 59 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 60 with seizures 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 61 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 62 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 63 with macrocephaly 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 64
           |   |__autosomal dominant intellectual developmental disorder 65 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 66 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 67 17 rec.
           |   |__autosomal dominant intellectual developmental disorder 68 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 69 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 70 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 71 with behavioral abnormalities 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 72 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 73 2 rec.
           |   |__autosomal dominant intellectual developmental disorder 74 1 rec.
           |   |__autosomal dominant intellectual developmental disorder 75 2 rec.
           |   |__autosomal dominant intellectual developmental disorder type FRA12A 1 rec.
           |   |__Bryant-Li-Bhoj neurodevelopmental syndrome(+) 2 rec.
           |   |__cerebellar ataxia type 47 1 rec.
           |   |__Clark-Baraitser syndrome 1 rec.
           |   |__Coffin-Siris syndrome(+) 32 rec.
           |   |__developmental delay, dysmorphic facies, and brain anomalies 9 rec.
           |   |__developmental delay, hypotonia, and impaired language 4 rec.
           |   |__GAND syndrome 2 rec.
           |   |__Helsmoortel-Van Der Aa Syndrome
           |   |__intellectual developmental disorder with autistic features and language delay, with or without seizures 4 rec.
           |   |__intellectual developmental disorder with dysmorphic facies and behavioral abnormalities 1 rec.
           |   |__intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies 15 rec.
           |   |__Luo-Schoch-Yamamoto syndrome 8 rec.
           |   |__NESCAV syndrome 2 rec.
           |   |__neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities 17 rec.
           |   |__neurodevelopmental disorder with dysmorphic facies and distal limb anomalies 1 rec.
           |   |__neurodevelopmental disorder with dysmorphic facies and thin corpus callosum 9 rec.
           |   |__neurodevelopmental disorder with eye movement abnormalities and ataxia 11 rec.
           |   |__neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures 1 rec.
           |   |__neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language 1 rec.
           |   |__neurodevelopmental disorder with or without autism or seizures 2 rec.
           |   |__neurodevelopmental disorder with speech impairment and dysmorphic facies 4 rec.
           |   |__Pierpont syndrome 1 rec.
           |   |__ReNU syndrome
           |   |__Schuurs-Hoeijmakers Syndrome 1 rec.
           |   |__Sifrim-Hitz-Weiss syndrome 2 rec.
           |   |__Vulto-van Silfout-de Vries syndrome 1 rec.
           |   |__White-Sutton syndrome 2 rec.
           |   |__Xia-Gibbs Syndrome
           |__autosomal recessive intellectual developmental disorder 201 rec.
           |   |__autosomal recessive intellectual developmental disorder 1 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 2 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 3 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 4
           |   |__autosomal recessive intellectual developmental disorder 5 10 rec.
           |   |__autosomal recessive intellectual developmental disorder 6 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 7 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 9/26
           |   |__autosomal recessive intellectual developmental disorder 10/20
           |   |__autosomal recessive intellectual developmental disorder 11
           |   |__autosomal recessive intellectual developmental disorder 12
           |   |__autosomal recessive intellectual developmental disorder 13 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 14 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 16
           |   |__autosomal recessive intellectual developmental disorder 18 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 23
           |   |__autosomal recessive intellectual developmental disorder 24
           |   |__autosomal recessive intellectual developmental disorder 25
           |   |__autosomal recessive intellectual developmental disorder 27 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 28
           |   |__autosomal recessive intellectual developmental disorder 29
           |   |__autosomal recessive intellectual developmental disorder 30
           |   |__autosomal recessive intellectual developmental disorder 31
           |   |__autosomal recessive intellectual developmental disorder 33
           |   |__autosomal recessive intellectual developmental disorder 34
           |   |__autosomal recessive intellectual developmental disorder 35
           |   |__autosomal recessive intellectual developmental disorder 37 3 rec.
           |   |__autosomal recessive intellectual developmental disorder 38 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 39
           |   |__autosomal recessive intellectual developmental disorder 40 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 41
           |   |__autosomal recessive intellectual developmental disorder 43 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 44 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 45
           |   |__autosomal recessive intellectual developmental disorder 46 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 47 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 48 3 rec.
           |   |__autosomal recessive intellectual developmental disorder 50 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 51
           |   |__autosomal recessive intellectual developmental disorder 52 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 54 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 56 9 rec.
           |   |__autosomal recessive intellectual developmental disorder 57 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 58 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 59 5 rec.
           |   |__autosomal recessive intellectual developmental disorder 60 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 61
           |   |__autosomal recessive intellectual developmental disorder 63 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 64 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 65 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 66 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 67 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 68 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 69 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 70 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 71 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 72 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 73 3 rec.
           |   |__autosomal recessive intellectual developmental disorder 74 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 75
           |   |__autosomal recessive intellectual developmental disorder 76 17 rec.
           |   |__autosomal recessive intellectual developmental disorder 77 1 rec.
           |   |__autosomal recessive intellectual developmental disorder 82 2 rec.
           |   |__autosomal recessive intellectual developmental disorder 83
           |   |__Brunet-Wagner neurodevelopmental syndrome 3 rec.
           |   |__early onset progressive encephalopathy with brain atrophy and thin corpus callosum 8 rec.
           |   |__glycosylphosphatidylinositol biosynthesis defect 16 1 rec.
           |   |__hyperphosphatasia with impaired intellectual development syndrome(+) 8 rec.
           |   |__infantile hypotonia with psychomotor retardation and characteristic facies-3 1 rec.
           |   |__intellectual developmental disorder with abnormal behavior, microcephaly, and short stature 4 rec.
           |   |__Kariminejad neurodevelopmental syndrome 1 rec.
           |   |__neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies 1 rec.
           |   |__neurodevelopmental disorder with cerebellar atrophy and motor dysfunction 3 rec.
           |   |__neurodevelopmental disorder with language delay and seizures 12 rec.
           |   |__neurodevelopmental disorder with microcephaly, absent speech, and hypotonia 1 rec.
           |   |__neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities 3 rec.
           |   |__neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy 3 rec.
           |   |__neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities 9 rec.
           |   |__neurodevelopmental disorder with poor growth and behavioral abnormalities 1 rec.
           |   |__neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss 5 rec.
           |   |__neurodevelopmental disorder with spastic paraplegia and microcephaly 1 rec.
           |   |__neurodevelopmental disorder with spasticity and poor growth 3 rec.
           |   |__Rafiq syndrome 1 rec.
           |   |__spastic tetraplegia, thin corpus callosum, and progressive microcephaly 1 rec.
           |__non-syndromic intellectual disability 65 rec.
           |   |__non-syndromic X-linked intellectual disability(+) 65 rec.
           |__syndromic intellectual disability 251 rec.
               |__desmosterolosis
               |__developmental delay and seizures with or without movement abnormalities 1 rec.
               |__Fliedner-Zweier syndrome 2 rec.
               |__intellectual developmental disorder with ocular anomalies and distinctive facial features 6 rec.
               |__intellectual disability-severe speech delay-mild dysmorphism syndrome 2 rec.
               |__Kaufman oculocerebrofacial syndrome 1 rec.
               |__mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations 1 rec.
               |__neurodevelopmental disorder with midbrain and hindbrain malformations 1 rec.
               |__Pan-Chung-Bellen syndrome 2 rec.
               |__Pitt-Hopkins-like syndrome 2 2 rec.
               |__syndromic X-linked intellectual disability(+) 123 rec.
               |__Tatton-Brown-Rahman syndrome
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Is a specific developmental disorder
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Synonyms
  • "mental retardation" RELATED
Secondary IDs
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NCI:C84392
SNOMEDCT_US_2023_03_01:1855002
UMLS_CUI:C0025362