FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term amyotrophic lateral sclerosis ID (Ontology) DOID:332 (Human Disease)
Definition A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing.
Also Known As "ALS" ; "Lou Gehrig's disease" ; "motor neuron disease, bulbar"
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DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS     197
Human Disease Models (FBhh)  DOID       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Human Disease Models
 amyotrophic lateral sclerosis     221    103      5
 ameliorates | amyotrophic lateral sclerosis      74       --       --
 exacerbates | amyotrophic lateral sclerosis      38       --       --
 for disease ribbon | Sandhoff disease       --       3       --
 for disease ribbon | Tay-Sachs disease       --       3       --
 model of | amyotrophic lateral sclerosis      98       --       --
 model of | Sandhoff disease       --       3       --
 model of | Tay-Sachs disease       --       3       --
 DOES NOT ameliorate | amyotrophic lateral sclerosis       3       --       --
 DOES NOT model | amyotrophic lateral sclerosis      13       --       --
Spanning Tree (Parents/Children)
Only view relationship: 
  neurodegenerative disease
   |__motor neuron disease
       |__amyotrophic lateral sclerosis  1903 rec.
           |__amyotrophic lateral sclerosis type 1 40 rec.
           |__amyotrophic lateral sclerosis type 2 12 rec.
           |__amyotrophic lateral sclerosis type 3
           |__amyotrophic lateral sclerosis type 4 7 rec.
           |__amyotrophic lateral sclerosis type 5 1 rec.
           |__amyotrophic lateral sclerosis type 6 247 rec.
           |__amyotrophic lateral sclerosis type 7
           |__amyotrophic lateral sclerosis type 8 276 rec.
           |__amyotrophic lateral sclerosis type 9 2 rec.
           |__amyotrophic lateral sclerosis type 10 507 rec.
           |__amyotrophic lateral sclerosis type 11 3 rec.
           |__amyotrophic lateral sclerosis type 12 1 rec.
           |__amyotrophic lateral sclerosis type 13
           |__amyotrophic lateral sclerosis type 15 31 rec.
           |__amyotrophic lateral sclerosis type 16 7 rec.
           |__amyotrophic lateral sclerosis type 18 6 rec.
           |__amyotrophic lateral sclerosis type 19 1 rec.
           |__amyotrophic lateral sclerosis type 20 5 rec.
           |__amyotrophic lateral sclerosis type 21 24 rec.
           |__amyotrophic lateral sclerosis type 22 5 rec.
           |__amyotrophic lateral sclerosis type 23 7 rec.
           |__amyotrophic lateral sclerosis type 24 6 rec.
           |__amyotrophic lateral sclerosis type 25 6 rec.
           |__amyotrophic lateral sclerosis type 26 3 rec.
           |__amyotrophic lateral sclerosis type 28
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 1 599 rec.
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 2 53 rec.
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 3 6 rec.
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 4 10 rec.
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 6 25 rec.
           |__frontotemporal dementia and/or amyotrophic lateral sclerosis 7 41 rec.
           |__juvenile amyotrophic lateral sclerosis type 27 1 rec.
           |__juvenile amyotrophic lateral sclerosis with dementia
           |__sporadic amyotrophic lateral sclerosis
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Is a motor neuron disease
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Synonyms
  • "ALS" EXACT OMO:0003012
    "Lou Gehrig's disease" EXACT
    "motor neuron disease, bulbar" EXACT
Secondary IDs
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GARD:5786
ICD10CM:G12.21
ICD9CM:335.20
KEGG:05014
MESH:D000690
MIM:PS105400
NCI:C34373
ORDO:803
SNOMEDCT_US_2023_03_01:86044005
UMLS_CUI:C0002736