FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term severe combined immunodeficiency ID (Ontology) DOID:627 (Human Disease)
Definition A combined T cell and B cell immunodeficiency that is caused by a defect in infection-fighting immune cells resulting in individuals with non-functional immune systems.
Also Known As "combined T and B cell inborn immunodeficiency" ; "SCID"
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  primary immunodeficiency disease
   |__combined immunodeficiency
       |__severe combined immunodeficiency  14 rec.
           |__adenosine deaminase deficiency
           |__CD3delta deficiency
           |__CD3epsilon deficiency
           |__CD3gamma deficiency
           |__CD3zeta deficiency
           |__CD45 deficiency
           |__coronin-1A deficiency 1 rec.
           |__immunodeficiency 11A
           |__immunodeficiency 15B 1 rec.
           |__immunodeficiency 19
           |__immunodeficiency 22 1 rec.
           |__immunodeficiency 24 1 rec.
           |__immunodeficiency 26 1 rec.
           |__immunodeficiency 121 3 rec.
           |__janus kinase-3 deficiency 1 rec.
           |__MHC class I deficiency 2 rec.
           |__MHC class II deficiency
           |__Omenn syndrome
           |__recombinase activating gene 1 deficiency
           |__recombinase activating gene 2 deficiency
           |__reticular dysgenesis 1 rec.
           |__severe combined immunodeficiency 104
           |__severe combined immunodeficiency 105 1 rec.
           |__severe combined immunodeficiency 124
           |__severe combined immunodeficiency with sensitivity to ionizing radiation
           |__severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive
           |__T-cell immunodeficiency, congenital alopecia, and nail dystrophy 1 rec.
           |__X-linked severe combined immunodeficiency
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Is a combined immunodeficiency
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Synonyms
  • "combined T and B cell inborn immunodeficiency" EXACT
    "SCID" EXACT OMO:0003012
Secondary IDs
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GARD:7628
MESH:D016511
NCI:C3472
SNOMEDCT_US_2023_03_01:190994004
UMLS_CUI:C0085110