FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term prion disease ID (Ontology) DOID:649 (Human Disease)
Definition A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins.
Also Known As "Prion disease pathway" ; "prion induced disorder" ; "Prion protein disease" (for all, see Synonyms field below)
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DO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Alleles (FBal)  HUMAN_DISEASE_INTERACTIONS      47
Human Disease Models (FBhh)  DOID       1
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Relevant FlyBase reports
 Alleles Genes Human Disease Models
 prion disease      49     22      1
 ameliorates | prion disease       6       --       --
 exacerbates | prion disease       9       --       --
 for disease ribbon | seborrheic keratosis       --       1       --
 model of | prion disease      32       --       --
 model of | seborrheic keratosis       --       1       --
 DOES NOT model | prion disease       2       --       --
Spanning Tree (Parents/Children)
Only view relationship: 
central nervous system disease
 |__brain disease________________
disease                          |
 |__disease by infectious agent__|
                                 prion disease  90 rec.
                                  |__chronic wasting disease
                                  |__Creutzfeldt-Jakob disease 13 rec.
                                  |__fatal familial insomnia 2 rec.
                                  |__Gerstmann-Straussler-Scheinker syndrome 5 rec.
                                  |__Huntington's disease-like 1
                                  |__kuru
                                  |__scrapie 8 rec.
                                  |__variant Creutzfeldt-Jakob disease
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Is a disease by infectious agent
brain disease
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Synonyms
  • "Prion disease pathway" EXACT
    "prion induced disorder" EXACT
    "Prion protein disease" EXACT
    "Spongiform Encephalopathy" EXACT
    "transmissible spongiform encephalopathy" EXACT
Secondary IDs
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ICD10CM:A81.9
KEGG:05020
MESH:D017096
NCI:C128346
SNOMEDCT_US_2023_03_01:20484008
UMLS_CUI:C0162534