FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nephrocyte ID (Ontology) FBbt:00047125 (Fly Anatomy)
Definition Cell that regulates hemolymph composition by filtration and filtrate endocytosis. Extensive infoldings of the plasma membrane generate a network of labyrinthine channels, known as lacunae, flanked by nephrocyte foot processes. The entrances to these channels take the form of narrow slits approximately 30 nm in width, spanned by single or double filaments that form a specialized filter known as the nephrocyte diaphragm. Each nephrocyte is enveloped in a negatively charged basement membrane so that hemolymph is filtered across basement membrane and the nephrocyte diaphragm and is endocytosed from the lacunae. Nephrocytes are derived from the embryonic mesoderm and many persist through metamorphosis into adult life.[ FlyBase:FBrf0031012 FlyBase:FBrf0209268 ]
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Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      59
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       1
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       1
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      48
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 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 nephrocyte (all annotations which use CV term, excluding "NOT" statements)      59      2      2     48
     nephrocyte | adult stage      11       --       --      10
     nephrocyte | larval stage      18       --       --      13
     nephrocyte | larval stage | progressive       2       --       --       2
     nephrocyte | third instar larval stage       4       --       --       4
Spanning Tree (Parents/Children)
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  cell
   |__somatic cell
       |__nephrocyte  1049 rec.
           |__garland cell 464 rec.
           |   |__adult garland cell 16 rec.
           |   |__embryonic garland cell 23 rec.
           |   |__embryonic/larval garland cell 380 rec.
           |__pericardial cell 588 rec.
               |__adult pericardial cell(+) 166 rec.
               |__embryonic pericardial cell(+) 130 rec.
               |__larval pericardial cell 277 rec.
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Is a somatic cell
Part of excretory system
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