Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Term | adult insulin secreting cell of pars intercerebralis | ID (Ontology) | FBbt:00110107 (Fly Anatomy) |
| Definition | Insulin-producing neurosecretory cell of the adult pars intercerebralis that innervates the corpus cardiacum and corpus allatum, and branches before exiting the brain. It extends thin branches laterally in the dorsal protocerebrum, shorter branches along the cell neurites in the dorsal part of the median bundle and has extensive arborizations in the tritocerebrum (Enell et al., 2010). A single axon extends ventrally, branching just before exiting the brain, emerging as two branches that follow the aorta and innervate the corpus cardiacum in the ring gland and the hypocerebral ganglion, near the cardiac valve of the midgut. One of the branches follows the stalk of the crop, whilst the other bifurcates, with each of these branches extending along each side of the midgut (Cao and Brown, 2001). There are approximately 7-9 of these cells from each hemisphere with their cell bodies clustering in the pars intercerebralis at late pupal stages (Cao and Brown, 2001, Broughton et al., 2005, Cao et al., 2014; McKim et al., 2024). These cells co-express Ilp2, Ilp3 and Ilp5 mRNA (Broughton et al., 2005).[ FlyBase:FBrf0134726 FlyBase:FBrf0136823 FlyBase:FBrf0184236 FlyBase:FBrf0212696 FlyBase:FBrf0224974 ] | ||
| Also Known As | "adult insulin producing cell of brain" ; "adult m-NSC DILP" | ||
| Comment | Insulin-producing cells are found amongst the median neurosecretory cells, but not all mNSCs are IPCs (FBrf0212696), despite misleading phrasing in some articles (e.g. FBrf0184236). | ||
| Links to External Ontologies | |||
| VFB:FBbt_00110107 | |||
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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supraesophageal ganglion neuron |__adult neurosecretory cell of pars intercerebralis__ peptidergic neuron | |__insulin secreting cell of pars intercerebralis_____| |__adult peptidergic neuron___________________________| adult neuron | |__adult gut-innervating neuron_______________________| |__adult peptidergic neuron___________________________| neurosecretory cell of pars intercerebralis | |__insulin secreting cell of pars intercerebralis_____| |__adult neurosecretory cell of pars intercerebralis__| efferent neuron | |__insulin secreting cell of pars intercerebralis_____| adult efferent neuron | |__adult ring gland projection neuron_________________| gut-innervating neuron | |__adult gut-innervating neuron_______________________| neurosecretory cell of adult brain | |__adult neurosecretory cell of pars intercerebralis__| adult insulin secreting cell of pars intercerebralis 100 rec. |__adult Drosulfakinin neuron of pars intercerebralis 1 rec. |
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insulin secreting cell of pars intercerebralis adult neurosecretory cell of pars intercerebralis adult gut-innervating neuron adult peptidergic neuron adult ring gland projection neuron |
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| VFB:FBbt_00110107 | |||