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Gene Dmel\LIMK1

General Information
Symbol	Dmel\LIMK1	Species	D. melanogaster
Name	LIM-kinase1	Annotation symbol	CG1848
Feature type	protein_coding_gene	FlyBase ID	FBgn0041203
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Dlimk, LIMK, DLIMK1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	11B2-11B2	Sequence location	X:12,478,418..12,486,226 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene LIM-kinase1 is referred to in FlyBase by the symbol Dmel\LIMK1 (CG1848, FBgn0041203). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: synapse assembly; regulation of axonogenesis; compound eye development; establishment of planar polarity; establishment of imaginal disc-derived wing hair orientation; protein phosphorylation; synaptic growth at neuromuscular junction. 18 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; thoracic segment; adult; adult antennal lobe; appendage segment; protocerebrum; mushroom body medial lobe; region of integument. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: PDZ/DHR/GLGF; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase-like domain; Zinc finger, LIM-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1641452_a_at completely aligns to an exonic region of only a subset of 2 of the 5 FlyBase-annotated transcript isoforms of LIMK1. Gene sequence location is X:12478418..12486226.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Sequence features BKN50251 BKN50067 BKN20292 HFA19811
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 11B2-11B2   Limits computationally determined from genome sequence between P{EP}CG11138EP1313 and P{EP}EP1632&P{EP}EP1449
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\LIMK1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone GM09639 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) LIMK1-RA FBtr0073659  NM_167326   4964   1235 LIMK1-RC FBtr0073660  NM_078584   5627   1257 LIMK1-RD FBtr0073661  NM_167327   4814   1052 LIMK1-RE FBtr0301830  NM_001169262   4520   1235 LIMK1-RF FBtr0301831  NM_001169263   4187   1043
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein LIMK1-PA   FBpp0073492   136.7   1235   8.84     NP_727621   AAF48176 LIMK1-PC   FBpp0073493   139.3   1257   8.76     NP_511139   AAN09311 LIMK1-PD   FBpp0073494   117.1   1052   9.88     NP_727622   AAN09312 LIMK1-PE   FBpp0291044   136.7   1235   8.84     NP_001162733   ACZ95268 LIMK1-PF   FBpp0291045   115.9   1043   9.59     NP_001162734   ACZ95269
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) PDZ/DHR/GLGF (IPR001478) Zinc finger, LIM-type (IPR001781) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440058   AA441464   AA735722   AA979204   AE014298 AAF48176   AE014298 AAN09311   AE014298 AAN09312   AB042816 BAB17233   AB042818 BAB17234   AE014298 ACZ95268   AE014298 ACZ95269   AI404032   AI945139   AW940913   AW942338   AY060966 AAL28514   AY119587 AAM50241   BE976632   BF487093   BF487809   BF488996   BF490696   BF492113   BF499666   BF501855   BF506461   BG638112   BG638714   BI167828   BI233030   BI358627   BI580066   BI580531   BT099664   CK658197   CL526041   CO187419   CO190778   CO273098   CO276155   CO279146   CO287275   CO304515   CO308448   CO344710   EC052526   EC053528   EC054014   EC054512   EC055359   EC055788   EC089113   EC210100   EC217936   EC218367   EC218544   EC220331   EC234690   EC256339   EV586602
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IR79 Q95S42 E1JJM7 E1JJM8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 2 -- 5   organism | ubiquitous & uniform   (Ohashi et al., 2000) Comment:decreasing with time
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0041203    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0041203 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0041203 expression level Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr  (1361) embryo 04-06hr  (722) embryo 06-08hr  (861) embryo 08-10hr  (1009) embryo 10-12hr  (741) embryo 12-14hr  (775) embryo 14-16hr  (887) embryo 16-18hr  (805) embryo 18-20hr  (655) embryo 20-22hr  (874) embryo 22-24hr  (817) larva L1  (344) larva L2  (202) larva L3 12hr old  (177) larva L3 puffstage 1-2  (226) larva L3 puffstage 3-6  (506) larva L3 puffstage 7-9  (546) white prepupae new  (567) white prepupae 12hr  (889) white prepupae 24hr  (1132) pupae 2d postWPP  (1032) pupae 3d postWPP  (839) pupae 4d postWPP  (776) adult male 01day  (1028) adult male 05day  (1469) adult male 30day  (1408) adult female 01day  (920) adult female 05day  (1233) adult female 30day  (1271) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day  1469 adult male 30day  1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0041203 expression level Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1630) embryo 02-04hr  (1361) embryo 04-06hr  (722) embryo 06-08hr  (861) embryo 08-10hr  (1009) embryo 10-12hr  (741) embryo 12-14hr  (775) embryo 14-16hr  (887) embryo 16-18hr  (805) embryo 18-20hr  (655) embryo 20-22hr  (874) embryo 22-24hr  (817) larva L1  (344) larva L2  (202) larva L3 12hr old  (177) larva L3 puffstage 1-2  (226) larva L3 puffstage 3-6  (506) larva L3 puffstage 7-9  (546) white prepupae new  (567) white prepupae 12hr  (889) white prepupae 24hr  (1132) pupae 2d postWPP  (1032) pupae 3d postWPP  (839) pupae 4d postWPP  (776) adult male 01day  (1028) adult male 05day  (1469) adult male 30day  (1408) adult female 01day  (920) adult female 05day  (1233) adult female 30day  (1271) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day  1469 adult male 30day  1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1630 embryo 02-04hr    1361 embryo 04-06hr    722 embryo 06-08hr    861 embryo 08-10hr    1009 embryo 10-12hr    741 embryo 12-14hr    775 embryo 14-16hr    887 embryo 16-18hr    805 embryo 18-20hr    655 embryo 20-22hr    874 embryo 22-24hr    817 larva L1    344 larva L2    202 larva L3 12hr old    177 larva L3 puffstage 1-2    226 larva L3 puffstage 3-6    506 larva L3 puffstage 7-9    546 white prepupae new    567 white prepupae 12hr    889 white prepupae 24hr    1132 pupae 2d postWPP    1032 pupae 3d postWPP    839 pupae 4d postWPP    776 adult male 01day    1028 adult male 05day    1469 adult male 30day    1408 adult female 01day    920 adult female 05day    1233 adult female 30day    1271 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0041203    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0041203 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0041203 expression level Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0041203 expression level Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    190.025 Larval Midgut    62 Larval Hindgut    79.1 Larval Malpighian Tubules    52.9 Larval Fat Body    43.7 Larval Salivary Gland    104.1 Larval Trachea    109.55 Larval Carcass    96.875 Adult Head    109.8 Adult Eye    120.375 Adult Brain    386.6 Adult Thoracic-Abdominal Ganglion    318.7 Adult Crop    110.9 Adult Midgut    94.9 Adult Hindgut    116.1 Adult Malpighian Tubules    40.9 Adult Fat Body    76.5 Adult Salivary Gland    189.1 Adult Heart    72.575 Adult VirginFemale Spermatheca    89.4 Adult InseminatedFemale Spermatheca    95.4 Adult Ovary    159.3 Adult Testis    12.2 Adult Male Accessory Gland    77.5 Adult Carcass    81.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    109.8   NA  Eye    120.375   NA  Brain    386.6   190.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    318.7   NA  Crop    110.9   62  Midgut    94.9   79.1  Hindgut    116.1   52.9  Malpighian Tubules    40.9   43.7  Fat Body    76.5   104.1  Salivary Gland    189.1   NA  Heart    72.575   109.55  Trachea    NA   NA  VirginFemale Spermatheca    89.4   NA  InseminatedFemale Spermatheca    95.4   NA  Ovary    159.3   NA  Testis    12.2   NA  Male Accessory Gland    77.5   96.875  Carcass    81.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041203 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1848-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4ap-md544 LIMK1Scer\UAS.T:Ivir\HA1 lethal | heat sensitive, with Scer\GAL4ap-md544 LIMK1ΔNgoMIV.Scer\UAS viable LIMK11 LIMK12 LIMK14 LIMK1EY08757 viable, with Scer\GAL4pnr-MD237 LIMK1GD9586 viable, with Scer\GAL4T80 LIMK1D522A.Scer\UAS Sterility Allele fertile LIMK11 LIMK12 LIMK14 LIMK1EY08757 fertile, with Scer\GAL4T80 LIMK1D522A.Scer\UAS Other Phenotypes Allele cell polarity defective, with Scer\GAL4ap-md544 LIMK1ΔNgoMIV.Scer\UAS neuroanatomy defective, with Scer\GAL4ey-OK107 LIMK1Scer\UAS.T:Ivir\HA1 neuroanatomy defective, with Scer\GAL4SG18.1 LIMK1kd.Scer\UAS.T:Hsap\MYC LIMK1Scer\UAS.T:Hsap\MYC visible, with Scer\GAL4en-e16E LIMK1Scer\UAS.cCa visible, with Scer\GAL4hs.PB LIMK1D522A.Scer\UAS visible, with Scer\GAL4T80 LIMK1D522A.Scer\UAS Phenotype manifest in Allele adult mushroom body, with Scer\GAL4ey-OK107 LIMK1Scer\UAS.T:Ivir\HA1 antennal lobe, with Scer\GAL4SG18.1 LIMK1Scer\UAS.T:Hsap\MYC LIMK1kd.Scer\UAS.T:Hsap\MYC antennal lobe glomerulus | ectopic, with Scer\GAL4SG18.1 LIMK1kd.Scer\UAS.T:Hsap\MYC antennal lobe glomerulus DM6, with Scer\GAL4SG18.1 LIMK1kd.Scer\UAS.T:Hsap\MYC antennal lobe glomerulus VA6, with Scer\GAL4SG18.1 LIMK1kd.Scer\UAS.T:Hsap\MYC dorsal mesothoracic disc & actin filament, with Scer\GAL4en-e16E LIMK1Scer\UAS.cCa femur, with Scer\GAL4T80 LIMK1D522A.Scer\UAS leg, with Scer\GAL4hs.PB LIMK1D522A.Scer\UAS leg, with Scer\GAL4T80 LIMK1D522A.Scer\UAS lobe system of mushroom body, with Scer\GAL4ey-OK107 LIMK1Scer\UAS.T:Ivir\HA1 mushroom body medial lobe, with Scer\GAL4ey-OK107 LIMK1Scer\UAS.T:Ivir\HA1 mushroom body vertical lobe, with Scer\GAL4ey-OK107 LIMK1Scer\UAS.T:Ivir\HA1 tibia, with Scer\GAL4T80 LIMK1D522A.Scer\UAS wing, with Scer\GAL4en-e16E LIMK1Scer\UAS.cCa wing, with Scer\GAL4T80 LIMK1D522A.Scer\UAS wing hair, with Scer\GAL4ap-md544 LIMK1ΔNgoMIV.Scer\UAS wing vein, with Scer\GAL4en-e16E LIMK1Scer\UAS.cCa
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of LIMK1 Class Mutagen Stocks Known lesion LIMK1EY08757 P-element activity 1 -- LIMK11 P-element activity 0 Yes LIMK12 P-element activity 0 Yes LIMK14 0 Yes LIMK1E591 0 --
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of LIMK1 Class Mutagen Stocks Known lesion LIMK1GD9586 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes LIMK1Scer\UAS.KI.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 2 Yes LIMK1Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes LIMK1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes LIMK1JF02063 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes LIMK1D522A.Scer\UAS in vitro construct - regulatory fusion 0 Yes LIMK1GMR.PV in vitro construct - regulatory fusion 0 Yes LIMK1HM05159 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes LIMK1kd.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes LIMK1Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes LIMK1Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes LIMK1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes LIMK1ΔNgoMIV.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)LIMK1-3 (Ang et al., 2006) Df(1)LIMK1-5 (Ang et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9586} NA P{TRiP.HM05159} NA P{TRiP.JF02063} NA P{UAS-LIMK1.B} NA P{UAS-LIMK1.C} NA P{UAS-LIMK1.D522A} NA P{UAS-LIMK1.IR} NA P{UAS-LIMK1.kd} NA P{UAS-LIMK1.KI} NA P{UAS-LIMK1.MYC} NA P{UAS-LIMK1.T:Ivir\HA1} NA P{UAS-LIMK1.ΔNgoMIV} NA characterization construct P{GMR-LIMK1.V} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}LIMK1EY08757 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
protein serine/threonine kinase activity inferred from direct assay (Ohashi et al., 2000)
Biological Process
CV term Evidence References
compound eye development inferred from genetic interaction with mbt (Menzel et al., 2007) establishment of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Blair et al., 2006) establishment of planar polarity inferred from mutant phenotype (Blair et al., 2006) protein phosphorylation inferred from direct assay (Ohashi et al., 2000) regulation of axonogenesis inferred from mutant phenotype (Ng and Luo, 2004) synapse assembly inferred from mutant phenotype (Ang et al., 2006) synaptic growth at neuromuscular junction inferred from mutant phenotype (Ang et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity (Chen et al., 2000) inferred from sequence or structural similarity with UniProtKB:P53667 (FlyBase, 1992-) non-traceable author statement (Ohashi, 2000.5.17) zinc ion binding inferred from electronic annotation with InterPro:IPR001781 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
actin cytoskeleton organization non-traceable author statement (Ohashi, 2000.5.17) protein phosphorylation non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions LIMK1 allele Gene References LIMK1D522A.Scer\UAS br (Chen et al., 2004) Sb (Chen et al., 2004) LIMK1Scer\UAS.cCa bs (Chen et al., 2004) dia (Chen et al., 2004) Pkn (Chen et al., 2004) Rho1 (Chen et al., 2004) RhoGAPp190 (Chen et al., 2004) RhoGEF2 (Chen et al., 2004) rok (Chen et al., 2004) LIMK1Scer\UAS.T:Ivir\HA1 Cdc42 (Ng and Luo, 2004) dia (Ng and Luo, 2004) Pak (Ng and Luo, 2004) pbl (Ng and Luo, 2004) Rac1 (Ng and Luo, 2004) Rho1 (Ng and Luo, 2004) RhoGAPp190 (Ng and Luo, 2004) RhoGEF2 (Ng and Luo, 2004) rok (Ng and Luo, 2004) SCAR (Ng and Luo, 2004) sif (Ng and Luo, 2004) ssh (Niwa et al., 2002, Ng and Luo, 2004) trio (Ng and Luo, 2004) tsr (Ng and Luo, 2004) unspecified Pak (Ang et al., 2006) Pten (Kiger et al., 2003) Rac2 (Ng and Luo, 2004) ssh (Niwa et al., 2002) tsr (Ang et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58605 DroID - A comprehensive database of gene and protein interactions. • FBgn0041203 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32207
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20901 Dere\GG19547 Dgri\GH24831 Dmoj\GI16163 Dper\GL25348 Dpse\GA14953 Dsec\GM11544 Dsim\GD15924 Dvir\GJ16656 Dwil\GK16124 Dyak\GE16209
Curated drosophilid orthologs	Dmir\CG1848 (Thornton, 2005.12.20) Dpse\GA14953
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000187-PA Aedes aegypti (mosquito) AGAP011710-PA Anopheles gambiae (mosquito) XP_396603.3 Apis mellifera (honey bee) 154430 Branchiostoma floridae (lancelet) BGIBMGA012778-PA Bombyx mori (silk worm) ENSBTAP00000041788 Bos taurus (bovine) ENSCAFP00000018366 Canis familiaris (dog) ENSCINP00000005976 Ciona intestinalis (sea squirt) CPIJ000717 Culex pipens (mosquito) ENSCPOP00000000664 Cavia porcellus (guinea pig) 165760 Capitella spl (polychaete worm) DDB0229851 Dictyostelium discoideum (amoeba) 314766 Daphnia pulex (daphnia) ENSDARP00000087620 Danio rerio (zebra fish) ENSECAP00000010917 Equus caballus (horse) ENSGACP00000011634 Gymnopilus aculeatus (mushroom) ENSGALP00000001609 Gallus gallus (chicken) 83299 Hypsipyla robusta (cedar shoot borer) ENSP00000336740 Homo sapiens (human) 103637 Lottia gigantea (owl limpet) ENSMODP00000017313 Monodelphis domestica (gray opossum) ENSMMUP00000004182 Macaca mulatta (rhesus monkey) ENSMUSP00000015137 Mus musculus (house mouse) 95939 Nematostella vectensis (starlet anemone) ENSOANP00000004643 Ornithorynchus anatinus (platypus) ENSORLP00000008588 Oryzias latipes (japanese killifish) PHUM008027-PA Pediculus humanus (human body louse) ENSPTRP00000032971 Pan troglodytes (chimpanzee) ENSRNOP00000001996 Rattus norvegicus (norway rat) XP_968975.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018947 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000040014 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022723 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19513 NV50209 LH16411 ISCW015511 FBgn0233750 FBgn0218126 FBgn0203840 FBgn0187573 FBgn0166487 JGI_V11_314766 FBgn0074979 FBgn0162932 FBgn0138912 FBgn0132286 FBgn0111749 FBgn0097907 CPIJ000717 BGIBMGA012778 GB16654 AGAP011710 AAEL000187 PHUM255000 GLEAN_15763
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	9118 y1 w*; P{UAS-LIMK1.KI}M8 9119 y1 w*; P{UAS-LIMK1.KI}F3 26294 y1 v1; P{TRiP.JF02063}attP2 9116 y1 w*; P{UAS-LIMK1.T:Ivir\HA1}M6 9117 y1 w*; P{UAS-LIMK1.T:Ivir\HA1}F4 17491 y1 w67c23 P{EPgy2}LIMK1EY08757 9240 y1 w*; P{UAS-LIMK1.IR}1.1; P{UAS-LIMK1.IR}2.1/TM3, Sb1
VDRC	v25343 w1118; P{GD9586}v25343 v25344 w1118; P{GD9586}v25344
Genomic Clones ( 2 )
	BACR39P03 BACR48G08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 46 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04472 GM09639 LD15137
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08936 AT14286 AT17428 AT21776 AT22866 AT24679 AT27255 AT28987 GM27789 LP14945 RE08308 RE29303 RE74194 RE74739
Other clones	19031 58027 154790 214473.9 bs09d09 bs54a06 CK01.34B.F7 CK01.61D.F1 CK01.69B.G9 CK01.145D.G5 Dmel_neb_014333_0079_1408 EC052526 EC053528 EC054014 EC054512 EC055359 EC055788 EK029216 EK049621 EK065420 EK109509 EK119827 EK133631 EK245001 EK258211 EP19751 GH23615 LD16409 LD33520
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0041203 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32207
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG1848 LIM-kinase (FlyBase, 1996-)
Additional comments	Source for merge of CG1848 LIM-kinase was sequence comparison (date:001028). (FlyBase, 1996-)
Other Comments
	LIMK1 is a regulator of tsr function and a downstream effector of Pak. (Ang et al., 2006) RNAi experiments show that dsRNA targetted at this gene suppresses the Pten-dsRNA-induced cell shape changes in Kc167 cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation. (Rogers et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078584 NM_167326 NM_167327 NM_001169262 NM_001169263 RefSeq (Proteins) • NP_511139 NP_727621 NP_727622 NP_001162733 NP_001162734 DDBJ / EMBL / GenBank • AA440058 AA735722 AAF48176 AAL28514 AAM50241 AAN09311 AAN09312 AB042816 AB042818 ACZ95268 ACZ95269 AI404032 AI945139 AW940913 AW942338 AY060966 AY119587 BAB17233 BAB17234 CL526041 Entrez Gene - A searchable database of RefSeq genes. • 32207 UniProtKB/TrEMBL • E1JJM7 E1JJM8 Q8IR79 Q95S42
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) PDZ/DHR/GLGF (IPR001478) Zinc finger, LIM-type (IPR001781) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58605 DroID - A comprehensive database of gene and protein interactions. • FBgn0041203 DRSC - Results from RNAi screens. • FBgn0041203 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041203 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1848-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041203 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32207 InParanoid A subset of ortholog calls from InParanoid. • AAEL000187-PA Aedes aegypti (mosquito) AGAP011710-PA Anopheles gambiae (mosquito) XP_396603.3 Apis mellifera (honey bee) 154430 Branchiostoma floridae (lancelet) BGIBMGA012778-PA Bombyx mori (silk worm) ENSBTAP00000041788 Bos taurus (bovine) ENSCAFP00000018366 Canis familiaris (dog) ENSCINP00000005976 Ciona intestinalis (sea squirt) CPIJ000717 Culex pipens (mosquito) ENSCPOP00000000664 Cavia porcellus (guinea pig) 165760 Capitella spl (polychaete worm) DDB0229851 Dictyostelium discoideum (amoeba) 314766 Daphnia pulex (daphnia) ENSDARP00000087620 Danio rerio (zebra fish) ENSECAP00000010917 Equus caballus (horse) ENSGACP00000011634 Gymnopilus aculeatus (mushroom) ENSGALP00000001609 Gallus gallus (chicken) 83299 Hypsipyla robusta (cedar shoot borer) ENSP00000336740 Homo sapiens (human) 103637 Lottia gigantea (owl limpet) ENSMODP00000017313 Monodelphis domestica (gray opossum) ENSMMUP00000004182 Macaca mulatta (rhesus monkey) ENSMUSP00000015137 Mus musculus (house mouse) 95939 Nematostella vectensis (starlet anemone) ENSOANP00000004643 Ornithorynchus anatinus (platypus) ENSORLP00000008588 Oryzias latipes (japanese killifish) PHUM008027-PA Pediculus humanus (human body louse) ENSPTRP00000032971 Pan troglodytes (chimpanzee) ENSRNOP00000001996 Rattus norvegicus (norway rat) XP_968975.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018947 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000040014 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022723 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/limkinase1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32207 modMine - Data generated by the modENCODE project. • FBgn0041203 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19513 NV50209 LH16411 ISCW015511 FBgn0233750 FBgn0218126 FBgn0203840 FBgn0187573 FBgn0166487 JGI_V11_314766 FBgn0074979 FBgn0162932 FBgn0138912 FBgn0132286 FBgn0111749 FBgn0097907 CPIJ000717 BGIBMGA012778 GB16654 AGAP011710 AAEL000187 PHUM255000 GLEAN_15763
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	CG1848 (Savvateeva-Popova et al., 2003, Morrison et al., 2000, Rogers et al., 2003, Perkins et al., 2009.3.31, Perkins et al., 2009) Dlimk (Blair et al., 2005, Blair et al., 2003, Chen et al., 2004, Chen et al., 2005, Umemori et al., 2007, Verdier et al., 2006) dLIMK (Ribaya et al., 2002, von Blume et al., 2009) DLIMK (Blair et al., 2002, Niwa et al., 2002, Ohashi et al., 2000, Goold and Davis, 2007) D-Limk (Menzel et al., 2007) D-LIMK1 (Mentzel et al., 2003) DLIMK1 (Ohashi, 2000.5.17, Eaton and Davis, 2005) dLIMK1 (Marques, 2005) LIMK (Lundquist, 2003, Jovceva et al., 2007, Zhang et al., 2011) Limk (Baum, 2002, Ang et al., 2006, Blair et al., 2006, Menzel et al., 2007) limk (Niwa et al., 2002) LimK (Simões et al., 2010) LIMK1 (Ng, 2008) LimK1 (Guenin et al., 2010) LIM-kinase 1 (Edwards et al., 2006)
Name Synonym	LIM-DOMAIN KINASE (Morrison et al., 2000) LIM domain protein kinase (Menzel et al., 2007) LIM kinase (Patel and Van Vactor, 2002, Settleman, 2001, Miller, 2002, Chen et al., 2005) LIM-kinase (Chen et al., 2000, ) Lim Kinase (Dilks and DiNardo, 2007) Lim kinase (Rogers et al., 2003, Rogers et al., 2003, Simões et al., 2010) Lim-kinase (Verdier et al., 2006) LIM-kinase 1 (Edwards et al., 2006) LIM-kinase1 (Ohashi, 2000.5.17, ) LIM Kinase1 (Eaton and Davis, 2005)
Secondary FlyBase IDs
	FBgn0030402
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 6 ) Review  ( 7 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 11 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Zhang et al., 2011, Development 138(3): 455--464 Regulation of cofilin phosphorylation and asymmetry in collective cell migration during morphogenesis. [FBrf0212692] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Simões et al., 2010, Dev. Cell 19(3): 377--388 Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation. [FBrf0211783] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...