FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term insulin secreting cell of pars intercerebralis ID (Ontology) FBbt:00004011 (Fly Anatomy)
Definition Insulin-producing neuron with a cell body in the pars intercerebralis. These cells coexpress the genes Insulin-like peptide (Ilp) 2, Ilp3 and Ilp5 (Reinhard et al., 2024). There are approximately 7-9 of these cells per hemisphere and they fasciculate with the nervus corporis cardiaci (McKim et al., 2024).[ FlyBase:FBrf0134726 FlyBase:FBrf0136823 FlyBase:FBrf0149175 FlyBase:FBrf0151837 FlyBase:FBrf0184236 FlyBase:FBrf0193772 FlyBase:FBrf0212696 FlyBase:FBrf0224974 FlyBase:FBrf0261099 ]
Also Known As "insulin producing cell of brain" ; "m-NSC DILP"
Comment Insulin-producing cells are found amongst the median neurosecretory cells, but not all mNSCs are IPCs (FBrf0212696), despite misleading phrasing in some articles (e.g. FBrf0184236).
Links to External Ontologies
VFB:FBbt_00004011
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       4
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       1
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 insulin secreting cell of pars intercerebralis (all annotations which use CV term, excluding "NOT" statements)       5     12      1      7
     insulin secreting cell of pars intercerebralis | P-stage       1       --       --       --
Spanning Tree (Parents/Children)
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neuron
 |__peptidergic neuron___________________________
neurosecretory cell of brain                     |
 |__neurosecretory cell of pars intercerebralis__|
CNS neuron                                       |
 |__efferent neuron______________________________|
                                                 insulin secreting cell of pars intercerebralis  161 rec.
                                                  |__adult insulin secreting cell of pars intercerebralis 100 rec.
                                                  |   |__adult Drosulfakinin neuron of pars intercerebralis 1 rec.
                                                  |__larval insulin secreting cell of pars intercerebralis 64 rec.
                                                      |__larval Drosulfakinin neuron of pars intercerebralis 1 rec.
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Is a peptidergic neuron
neurosecretory cell of pars intercerebralis
efferent neuron
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Synonyms
  • "dorsomedial neurosecretory cell" BROAD
    "insulin producing cell of brain" EXACT
    "IPC" BROAD
    "m-NSC DILP" EXACT[ FlyBase:FBrf0261099 ]
Secondary IDs
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VFB:FBbt_00004011