FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term dopaminergic PPM2 neuron ID (Ontology) FBbt:00100217 (Fly Anatomy)
Definition A dopaminergic neuron whose cell body is located in a cluster of approximately 8 cell bodies in the cortex of the posterior inferior medial protocerebrum of the adult brain (Mao and Davis, 2009). Different subtypes develop from the DM2, DM3 and DM4 neuroblasts (Ren et al., 2016).[ FlyBase:FBrf0048550 FlyBase:FBrf0208427 FlyBase:FBrf0233706 ]
Also Known As "DM cell cluster neuron" ; "PPM2" ; "PPM2 cluster neuron" (for all, see Synonyms field below)
Comment Mao and Davis (2009) identify 8 protocerebral clusters coincidentally positive for TH-GAL4 activity and tyrosine hydroxylase immunoreactivity, implying these cells are dopaminergic. The cluster of PPM2 neurons was judged by a curator to correspond to the DM cell cluster in Budnik and White (1988). Hartenstein et al. (2017) - FBrf0234128 show that the larval DM2 cluster (primary DPMpm1/2 lineages) becomes the adult PPM2 cluster, but unclear whether any adult cells do not derive from functional larval primary neurons.
Links to External Ontologies
VFB:FBbt_00100217
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      54
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       5
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       4
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      51
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 Full annotation statements 
Relevant FlyBase reports
 Alleles  Genes Insertions Constructs
 dopaminergic PPM2 neuron (all annotations which use CV term, excluding "NOT" statements)      54      2      2      9     69
     dopaminergic PPM2 neuron | adult stage      21       --       --       2     18
     dopaminergic PPM2 neuron | adult stage | chemical conditional       3       --       --       --       3
     dopaminergic PPM2 neuron | adult stage | decreased number       9       --       --       --      14
     dopaminergic PPM2 neuron | adult stage | increased number       2       --       --       --       2
     dopaminergic PPM2 neuron | adult stage | progressive       7       --       --       --       7
     dopaminergic PPM2 neuron | decreased number       8       --       --       1      5
     dopaminergic PPM2 neuron | progressive       5       --       --       --       4
Spanning Tree (Parents/Children)
Only view relationship:
dopaminergic neuron
 |__adult dopaminergic neuron________
adult neuron                         |
 |__adult CNS neuron_________________|
adult aminergic neuron               |
 |__adult dopaminergic neuron________|
CNS neuron                           |
 |__supraesophageal ganglion neuron__|
 |__adult CNS neuron_________________|
                                     dopaminergic PPM2 neuron  196 rec.
                                      |__LAL neuron of the dopaminergic PPM2 cluster 26 rec.
                                      |__LAL-SEG neuron of the dopaminergic PPM2 cluster 43 rec.
                                      |__VLP neuron of the dopaminergic PPM2 cluster 36 rec.
                                      |__VLP-AMMC neuron of the dopaminergic PPM2 cluster 39 rec.
                                      |__VLP-SAD neuron of the dopaminergic PPM2 cluster 34 rec.
                                      |__WED neuron of the dopaminergic PPM2 cluster 53 rec.
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Is a supraesophageal ganglion neuron
adult dopaminergic neuron
adult CNS neuron
Part of adult brain
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Synonyms
  • "DM cell cluster neuron" EXACT[ FlyBase:FBrf0048550 ]
    "PPM2" EXACT VFB_SYMBOL[ FlyBase:FBrf0208427 ]
    "PPM2 cluster neuron" EXACT
    "protocerebral posteriomedial dopaminergic cluster neuron 2" RELATED
    "protocerebral posterior medial dopaminergic cluster neuron 2" RELATED
    "TH-positive posterior medial cluster neuron 2" EXACT
Secondary IDs
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VFB:FBbt_00100217