FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term type II neuroblast ID (Ontology) FBbt:00100533 (Fly Anatomy)
Definition Neuroblast that divides asymmetrically regenerate itself and produce a smaller intermediate neural progenitor (INP), which can produce multiple ganglion mother cells (Boone and Doe, 2008, Viktorin et al., 2011; Ren et al., 2016). Each type II neuroblast can produce multiple INPs, leading to the generation of multiple sublineages and typically more progeny than type I neuroblasts (Ren et al., 2016). It arises relatively late during embryonic development, delaminating from the dorsal cephalic neuroectoderm during stages 11-15 (Walsh and Doe, 2017). These cells and any existing INPs enter quiescence shortly before larval hatching (Walsh and Doe, 2017). There are eight type II neuroblasts per hemisphere, all belonging to the brain (Walsh and Doe, 2017).[ FlyBase:FBrf0204899 FlyBase:FBrf0207387 FlyBase:FBrf0209927 FlyBase:FBrf0214289 FlyBase:FBrf0214495 FlyBase:FBrf0233706 FlyBase:FBrf0237530 ]
Also Known As "TA neuroblast" ; "transiently amplifying neuroblast" ; "transit amplifying neuroblast"
Comment Bayraktar et al. (2010) show that type II neuroblasts can be distinguished from type I neuroblasts as being Deadpan-positive, but Prospero- and Asense-negative. Walsh and Doe (2017) also use pointed as a positive marker. Arise later than NBs of embryonic NB map in Urbach and Technau (2003) - FBrf0173125 (Walsh and Doe, 2017).
Links to External Ontologies
VFB:FBbt_00100533
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN     196
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       2
Insertions (FBti)  PHENOTYPE_MANIFEST_IN      12
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN     140
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 type II neuroblast (all annotations which use CV term, excluding "NOT" statements)     196     10     14    143
     type II neuroblast | adult stage | increased number       3       --       --       2
     type II neuroblast | decreased number | larval stage      26       --       --      25
     type II neuroblast | decreased number | larval stage | somatic clone       2       --       2       --
     type II neuroblast | ectopic | somatic clone | third instar larval stage       2       --       --       3
     type II neuroblast | embryonic stage       1       --       --       --
     type II neuroblast | increased number      27       --       2     17
     type II neuroblast | increased number | larval stage      32       --       3     21
     type II neuroblast | increased number | larval stage | somatic clone       3       --       --       --
     type II neuroblast | increased number | third instar larval stage      16       --       --      16
     type II neuroblast | larval stage      34       --       1     28
     type II neuroblast | larval stage | increased number      18       --       --      12
     type II neuroblast | larval stage | somatic clone      11       --       2       --
     type II neuroblast | larval stage | somatic clone | increased number      17       --       --       8
     type II neuroblast | larval stage | temperature conditional       1       --       --       --
     type II neuroblast | P-stage | increased number       3       --       --       2
     type II neuroblast | P-stage | increased number | somatic clone       2       --       --       2
     type II neuroblast | somatic clone       5       --       --       4
     type II neuroblast | somatic clone | increased number       7       --       --       1
     type II neuroblast | somatic clone | increased number | third instar larval stage       3       --       --       1
     type II neuroblast | somatic clone | third instar larval stage      11       --       --       4
     type II neuroblast | third instar larval stage      23       --       --      21
Spanning Tree (Parents/Children)
Only view relationship:
neuroblast____________________
anterior ectoderm derivative__|
                              procephalic neuroblast
                               |__type II neuroblast  363 rec.
                                   |__central complex neuroblast
                                   |   |__neuroblast CM4
                                   |   |__neuroblast DPMm1
                                   |   |__neuroblast DPMpm1
                                   |   |__neuroblast DPMpm2
                                   |__neuroblast CM1
                                   |__neuroblast CM3
                                   |__neuroblast CP2
                                   |__neuroblast CP3
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Synonyms
  • "TA neuroblast" EXACT
    "transiently amplifying neuroblast" EXACT
    "transit amplifying neuroblast" EXACT
Secondary IDs
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VFB:FBbt_00100533