|
General Information
|
| Term |
misexpression element |
ID (Ontology) |
FBcv:0005074 (FlyBase CV) |
| Definition |
The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern.[ FlyBase:FBrf0090768 ] |
| Comment |
|
|
Links to External Ontologies
|
|
|
|
Annotations
|
|
Records annotated with this term OR any of its CHILD TERMS
|
|
|
|
Records annotated with this exact term (annotations to child terms are NOT included)
|
|
No relevant records available
|
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
|
| Full annotation statements | Relevant FlyBase reports |
|---|
| Constructs |
|---|
misexpression element (all annotations which use CV term, excluding "NOT" statements) | 35 |
|
Relationships