FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term neuroblast NB2-4 ID (Ontology) FBbt:00001411 (Fly Anatomy)
Definition Neuroblast that delaminates at S4 and generates a contralaterally projecting motorneuron and approximately 8 local interneurons (Schmid et al., 1999). In the embryo, one of these cells can be found in each hemisegment from T1-A8 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in T2-A1 (Lacin and Truman, 2016). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 18 (Lacin and Truman, 2016).[ FlyBase:FBrf0112030 FlyBase:FBrf0221210 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As "lineage 18 neuroblast" ; "lineage NB2-4 neuroblast" ; "NB 18" (for all, see Synonyms field below)
Comment Birkholz et al. (2015) suggest that NB2-4 generates postembryonic lineage 8 and NB3-4 generates postembryonic lineage 18, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB2-4 generates lineage 18. Lacin and Truman (2016) Fig1S1 shows postembryonic NB2-4 in T1, but text and Fig3 shows loss of NB2-4 in T1 in the late embryo.
Links to External Ontologies
VFB:FBbt_00001411
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       4
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       6
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Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 neuroblast NB2-4 (all annotations which use CV term, excluding "NOT" statements)       6      7      6      3
Spanning Tree (Parents/Children)
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neuroblast
 |__stage 4 neuroblast_______________
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB2-4  24 rec.
                                      |__abdominal neuroblast NB2-4 2 rec.
                                      |   |__abdominal 1 neuroblast NB2-4
                                      |__thoracic neuroblast NB2-4
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Is a stage 4 neuroblast
segmentally-repeated neuroblast
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VFB:FBbt_00001411