FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term neuroblast NB5-4 ID (Ontology) FBbt:00001416 (Fly Anatomy)
Definition Neuroblast that most frequently delaminates at S4 (Schmid et al., 1997). In the embryo, one of these cells can be found in each hemisegment from S3-A10 (Birkholz et al., 2013; Urbach et al., 2016). In the larva, it resumes proliferation in all thoracic segments (Lacin and Truman, 2016) and in the male abdominal 9 neuromere (Birkholz et al., 2013). The neurons that develop from this neuroblast after larval hatching form postembryonic lineage 22 (Lacin and Truman, 2016).[ FlyBase:FBrf0098344 FlyBase:FBrf0112030 FlyBase:FBrf0180161 FlyBase:FBrf0221210 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As "lineage 22 neuroblast" ; "lineage NB5-4 neuroblast" ; "NB 22" (for all, see Synonyms field below)
Comment Using DiI with antibody labelling, Schmidt et al. (1997) propose NB5-4 produces 5-9 thoracic neurons or 3-4 abdominal motorneurons with ipsilateral targets. Schmid et al. (1999), also use DiI with en-GFP, but find 2-3 large cells that match descriptions of CCAP/CAP+ neurosecretory cells, along with abdomen-specific interneurons. Also, Schmid et al. (1999) state that NB5-4 delaminates during S5, whilst Schmidt et al. (1997) find that delamination occurs over the period of S3/4 to S5, most frequently at S4, and as such we have chosen to define NB5-4 as a stage 4 neuroblast.
Links to External Ontologies
VFB:FBbt_00001416
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       3
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       3
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 Full annotation statements 
Relevant FlyBase reports
 Alleles  Genes Insertions Constructs
 neuroblast NB5-4 (all annotations which use CV term, excluding "NOT" statements)       4      1      7      3      5
Spanning Tree (Parents/Children)
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neuroblast
 |__stage 4 neuroblast_______________
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB5-4  20 rec.
                                      |__abdominal neuroblast NB5-4
                                      |   |__abdominal 9 neuroblast NB5-4(+)
                                      |__labial neuroblast NB5-4
                                      |__thoracic neuroblast NB5-4
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Is a stage 4 neuroblast
segmentally-repeated neuroblast
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VFB:FBbt_00001416