FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term neuroblast NB2-3 ID (Ontology) FBbt:00001421 (Fly Anatomy)
Definition Neuroblast that delaminates at S5 and produces a primary lineage, of approximately 10 neurons, in thoracic segments only (Schmid et al., 1999; Birkholz et al., 2013; Lacin and Truman, 2016; Urbach et al., 2016). These primary neurons are mainly immature motor neurons that will connect to muscle targets in the adult (Lacin and Truman, 2016). In abdominal hemisegments it can be observed at embryonic stage 17, but it either does not divide or all progeny die (Schmid et al., 1999). In the larva, it resumes proliferation in all thoracic segments and generates postembryonic lineage 15, consisting of a large number of leg motor neurons and glia (Lacin and Truman, 2016).[ FlyBase:FBrf0055900 FlyBase:FBrf0084809 FlyBase:FBrf0112030 FlyBase:FBrf0221210 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As "lineage 15 neuroblast" ; "lineage NB2-3 neuroblast" ; "NB 15" (for all, see Synonyms field below)
Comment Originally referred to as NB1-2 by Doe (1992), this was renamed to NB2-3 by Broadus et al. (1995) to keep the names of row 2 neuroblasts consistent with their position in Schistocerca. Birkholz et al. (2015) suggest that NB2-3 does not generate a postembryonic lineage and NB3-2 generates postembryonic lineage 15, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB2-3 generates lineage 15.
Links to External Ontologies
VFB:FBbt_00001421
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       1
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       4
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Relevant FlyBase reports
 Alleles  Genes Insertions Constructs
 neuroblast NB2-3 (all annotations which use CV term, excluding "NOT" statements)       2      2      5      4      3
Spanning Tree (Parents/Children)
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neuroblast
 |__stage 5 neuroblast_______________
 |__neuroglioblast___________________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB2-3  16 rec.
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Is a stage 5 neuroblast
neuroglioblast
segmentally-repeated neuroblast
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VFB:FBbt_00001421