FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term perineurium ID (Ontology) FBbt:00007090 (Fly Anatomy)
Definition The outer two layers of glial cells that cover the central nervous system and the nerves. The outer layer is the perineurial glial sheath (sometimes referred to as the perineurial sheath outer layer); the inner layer is the subperineurial glial sheath (sometimes referred to as the perineurial sheath inner layer).[ FlyBase:FBrf0057603 FlyBase:FBrf0191040 FlyBase:FBrf0226917 FlyBase:FBrf0239343 ]
Comment Some authors use this term only to refer to the double layer of cells covering the CNS (e.g. Hartenstein and Jan, 1992), while other authors use it more broadly to include the covering of nerves (e.g. Banerjee et al., 2006). This ontology uses the term in its broad sense. 'Blood-brain barrier' may refer to this (e.g. Limmer et al., 2014) or the subperineurial glial sheath alone (e.g. Morante et al., 2013).
Links to External Ontologies
VFB:FBbt_00007090
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      27
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       5
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN      14
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 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 perineurium (all annotations which use CV term, excluding "NOT" statements)      27      1      5     14
     perineurium | adult stage       9       --       1      7
     perineurium | embryonic stage      14       --       4      3
     perineurium | larval stage      14       --       2     12
     perineurium | P-stage       2       --       --       1
Spanning Tree (Parents/Children)
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  multicellular structure
   |__multi-tissue structure
       |__perineurium  821 rec.
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Is a multi-tissue structure
Part of nervous system
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VFB:FBbt_00007090