FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term subperineurial glial sheath ID (Ontology) FBbt:00007091 (Fly Anatomy)
Definition Inner glial cell layer of the perineurium that is probably not derived from the mesoderm (Edwards et al., 1994). This layer form an ion permeability barrier, functionally similar to the endothelial cells of the mammalian blood-brain barrier (Limmer et al., 2014).[ FlyBase:FBrf0057603 FlyBase:FBrf0058936 FlyBase:FBrf0226917 FlyBase:FBrf0239343 ]
Also Known As "barrier glial cell layer" ; "sub-perineurial glial sheath"
Comment That the subperineurial glial cells do not derive from the mesoderm is suggested by Edwards et al. (1994), in which they show the presence of these cells in delta (FBgn0000463) mutant embryos. 'Blood-brain barrier' may refer to this (e.g. Morante et al., 2013) or the perineurium (e.g. Limmer et al., 2014), which includes this and the perineurial glial sheath.
Links to External Ontologies
VFB:FBbt_00007091
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       4
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Alleles Insertions
 subperineurial glial sheath (all annotations which use CV term, excluding "NOT" statements)       4      2
     subperineurial glial sheath | adult stage       1      1
Spanning Tree (Parents/Children)
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  multicellular structure
   |__portion of tissue
       |__subperineurial glial sheath  235 rec.
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Is a portion of tissue
Part of perineurium
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Synonyms
  • "barrier glial cell layer" EXACT
    "blood-brain barrier" RELATED[ FlyBase:FBrf0223187 ]
    "sub-perineurial glial sheath" EXACT
Secondary IDs
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VFB:FBbt_00007091