FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term dopaminergic PPL2ab neuron ID (Ontology) FBbt:00100220 (Fly Anatomy)
Definition A dopaminergic neuron whose cell body is located in a cluster of approximately 6-7 cell bodies in the cortex of the posterior inferior lateral protocerebrum of the adult brain (Mao and Davis, 2009). Members of this group send processes to various parts of the brain: one group send processes to the calyx, the inferior portion of the lateral horn and broad areas in the middle superior medial protocerebrum; another group sends processes to the calyx, the entire lateral horn and broad areas of the middle superior protocerebrum; another subgroup innervates the lobula and broad protocerebral areas; and a final group innervates the posterior lateral protocerebrum.[ FlyBase:FBrf0055596 FlyBase:FBrf0208427 FlyBase:FBrf0216686 ]
Also Known As "adult dopaminergic PPL2p neuron" ; "PPL neuron" ; "PPL2ab" (for all, see Synonyms field below)
Comment Mao and Davis (2009) identify 8 protocerebral clusters coincidentally positive for TH-GAL4 activity and tyrosine hydroxylase immunoreactivity, implying these cells are dopaminergic. The cluster of neurons is so named because it appears to correspond to a double cluster (called PPL2ab) of TH-positive neurons in the blow fly (Nassel and Elekes, 1992), though Mao and Davis (2009) were unable to identify two subclusters. Hartenstein et al. (2017) - FBrf0234128 call PPL2ab "PPL2a" and "PPL2p", and call PPL2c "PPL2b" and "PPL2d".
Links to External Ontologies
VFB:FBbt_00100220
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN       7
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       4
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN       7
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 Full annotation statements 
Relevant FlyBase reports
 Alleles  Genes Insertions Constructs
 dopaminergic PPL2ab neuron (all annotations which use CV term, excluding "NOT" statements)       7      3      2      4     27
     dopaminergic PPL2ab neuron | adult stage       3       --       --       --       3
     dopaminergic PPL2ab neuron | progressive       2       --       --       --       2
Spanning Tree (Parents/Children)
Only view relationship: 
neuron
 |__primary neuron___________________
dopaminergic neuron                  |
 |__adult dopaminergic neuron________|
ectodermal derivative                |
 |__anterior ectoderm derivative_____|
adult neuron                         |
 |__adult CNS neuron_________________|
adult aminergic neuron               |
 |__adult dopaminergic neuron________|
CNS neuron                           |
 |__supraesophageal ganglion neuron__|
 |__adult CNS neuron_________________|
                                     dopaminergic PPL2ab neuron  73 rec.
                                      |__ALT neuron of the dopaminergic PPL2ab cluster 12 rec.
                                      |__ALT-PLPC neuron of the dopaminergic PPL2ab cluster 19 rec.
                                      |__LH-CA neuron of the dopaminergic PPL2ab cluster 24 rec.
                                      |__SLP neuron of the dopaminergic PPL2ab cluster 18 rec.
                                      |__vLH-CA neuron of the dopaminergic PPL2ab cluster 8 rec.
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Is a supraesophageal ganglion neuron
anterior ectoderm derivative
primary neuron
adult dopaminergic neuron
adult CNS neuron
Develops from larval dopaminergic DL2a neuron
Part of adult brain
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Synonyms
  • "adult dopaminergic PPL2p neuron" EXACT[ FlyBase:FBrf0234128 ]
    "PPL neuron" EXACT[ FlyBase:FBrf0221624 ]
    "PPL2ab" EXACT VFB_SYMBOL[ FlyBase:FBrf0208427 ]
    "PPL2ab cluster neuron" EXACT
    "protocerebral posteriolateral dopaminergic cluster neuron 2ab" EXACT
    "protocerebral posterior lateral dopaminergic cluster neuron 2ab" EXACT
    "TH-positive posteriolateral dopaminergic cluster neuron 2ab" EXACT
Secondary IDs
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VFB:FBbt_00100220