FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term apterous-expressing neuron of the lateral cluster of the thorax Ap4 ID (Ontology) FBbt:00110872 (Fly Anatomy)
Definition Apterous-expressing neuron of the lateral cluster that expresses the neuropeptide FMRFamide and is the last neuron of the cluster to be generated, after the Ap3 neuron (Benveniste et al., 1998; Baumgardt et al., 2007; Baumgardt et al., 2009). It projects its axon medially, below the ventrolateral, central lateral and central intermediate tracts and approaches the dorsal median tract from below, where it arborizes extensively (Santos et al., 2007). Unlike other Ap neurons, it innervates a thoracic dorsal neurohemal organ (Baumgardt et al., 2007).[ FlyBase:FBrf0106026 FlyBase:FBrf0167500 FlyBase:FBrf0184217 FlyBase:FBrf0195184 FlyBase:FBrf0201188 FlyBase:FBrf0209429 ]
Also Known As "Ap4 neuron" ; "Ap4/FMRFa neuron" ; "dFMRFa neuron" (for all, see Synonyms field below)
Comment This neuron has been identified as neurosecretory because it expresses the neuropeptide FMRFamide (FBgn0000715) and innervates a neurohemal organ (Benveniste et al., 1998; Marques et al., 2003; Santos et al., 2007).
Links to External Ontologies
VFB:FBbt_00110872
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Alleles (FBal)  PHENOTYPE_MANIFEST_IN      89
Insertions (FBti)  EXPRESSION_STAGE_TISSUE_POSITION       8
Insertions (FBti)  PHENOTYPE_MANIFEST_IN       3
Constructs (FBtp)  PHENOTYPE_MANIFEST_IN       2
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 Full annotation statements 
Relevant FlyBase reports
 Alleles Genes Insertions Constructs
 apterous-expressing neuron of the lateral cluster of the thorax Ap4 (all annotations which use CV term, excluding "NOT" statements)      90     13     11      7
     apterous-expressing neuron of the lateral cluster of the thorax Ap4 | embryonic stage       1       --       --       --
     apterous-expressing neuron of the lateral cluster of the thorax Ap4 | first instar larval stage       2       --       2       --
     apterous-expressing neuron of the lateral cluster of the thorax Ap4 | increased number      18       --       --       --
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larval neuron
 |__larval neurosecretory neuron_____________________________________
neurosecretory neuron                                                |
 |__endocrine neuron_________________________________________________|
 |__larval neurosecretory neuron_____________________________________|
endocrine cell                                                       |
 |__endocrine neuron_________________________________________________|
larval thoracic NB5-6 primary interneuron                            |
 |__apterous-expressing neuron of the lateral cluster of the thorax__|
                                                                     apterous-expressing neuron of the lateral cluster of the thorax Ap4  121 rec.
                                                                      |__larval mesothoracic Ap4 neuron
                                                                      |__larval metathoracic Ap4 neuron
                                                                      |__larval prothoracic Ap4 neuron
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Is a endocrine neuron
larval neurosecretory neuron
apterous-expressing neuron of the lateral cluster of the thorax
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VFB:FBbt_00110872