FB2025_01 , released February 20, 2025
Allele: Dmel\parahd8
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General Information
Symbol
Dmel\parahd8
Species
D. melanogaster
Name
FlyBase ID
FBal0013477
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P{KP} element insertion in the 2nd intron, 279bp upstream of exon 3.

2.6 kb insert at 42.3-43 kb (2nd insert at -3.3 to -2.8 kb retained in revertants) P element at 14C-D

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies are sensitive to ether (lower concentrations are required for anaesthesia compared to wild-type flies).

hybrid dysgenesis gives partial reversion with loss of insert

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Excision of the P{KP} element reverts the phenotype. Order of sensitivity to ether anaesthesia is (most sensitive to least sensitive): parahd8 > parats3 > parats1. Order of sensitivity to heat induced paralysis is (lower temperature for 50% paralysis to higher temperature for 50% paralysis): parats3 > parats1 > parahd8.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
parahd8
Name Synonyms
Secondary FlyBase IDs
    References (4)