FB2025_01 , released February 20, 2025
Allele: Dmel\woc468
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General Information
Symbol
Dmel\woc468
Species
D. melanogaster
Name
FlyBase ID
FBal0212642
Feature type
allele
Associated gene
Dmel\woc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Raffa et al., 2005)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Raffa et al., 2005)

Amino acid replacement: ?755term.

(Raffa et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:27,260,780..27,260,780 [-]
Nucleotide change:

C27260780T

Reported nucleotide change:

C?T

Amino acid change:

R755term | woc-PA; R770term | woc-PB; R754term | woc-PD; R769term | woc-PE

Reported amino acid change:

?755term

(Raffa et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar homozygous larvae fail to pupariate and survive as wandering larvae for up to two weeks.

      The brains of homozygous and woc468/wocrgl larvae show a high frequency of telomere-telomere attachments compared to controls. Single telomere attachments in which a single telomere fuses with its sister telomere, or in which a single telomere fuses with another single nonsister telomere are both seen. Double telomere attachments, where a pair of sister telomeres join with another pair are seen; both monocentric ring chromosomes and linear dicentric chromosomes are seen. In addition, multiple double telomere attachments, resulting in multicentric rings or linear chromosomes, are also seen. The average number of telomere-telomere attachments per cell is 2.27 in homozygotes and 2.63 in woc468/wocrgl animals.

      Polytene chromosomes derived from homozygous larvae are thinner than their wild-type counterparts but show an overall normal banding pattern.

      (Raffa et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: A mutation that shows frequent telomere-telomere attachments in cells of the larval brain.

      (Raffa et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      woc468
      (Maimon et al., 2014, Noyes et al., 2011, Raffa et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)