FB2025_01 , released February 20, 2025
Allele: Dmel\paraF1845Y
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General Information
Symbol
Dmel\paraF1845Y
Species
D. melanogaster
Name
FlyBase ID
FBal0346886
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Samantsidis et al., 2019)
gene targeting by homologous recombination
(Samantsidis et al., 2019)
Progenitor genotype
Cytology
Description

A mutation equivalent to amino acid substitution F1845Y in the P. xylostella voltage-gated sodium channel gene has been introduced into the endogenous para locus.

(Samantsidis et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      paraF1845Y homozygous (female)/hemizygous (male) second instar larvae exposed to insecticides exhibit highly increased resistance to indoxacarb and metaflumizone compared controls.

      (Samantsidis et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      F1845Y
      (Samantsidis et al., 2019)
      paraF1845Y
      Name Synonyms
      Secondary FlyBase IDs
        References (1)