FB2025_01 , released February 20, 2025
Allele: Dmel\Tmem4318
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General Information
Symbol
Dmel\Tmem4318
Species
D. melanogaster
Name
FlyBase ID
FBal0376122
Feature type
allele
Associated gene
Dmel\Tmem43
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Klinke et al., 2022)
Mutagen
CRISPR/Cas9
(Klinke et al., 2022)
Progenitor genotype
Cytology
Description

A small deletion that causes a frame shift with a premature opal stop at codon 18.

(Klinke et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:7,915,004..7,915,005 [-]
Inserted_sequence:

A

Comment:

A 2bp deletion and the insertion of an A in codon 10 of Tmem43 leads to a frameshift and early translation termination after the addition of 9 novel amino acids.

(Paululat, 2022.9.16)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG8111*18
      (Klinke et al., 2022)
      Tmem4318
      Name Synonyms
      Secondary FlyBase IDs
        References (2)