FB2025_01 , released February 20, 2025
Chemical: Y-27632
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General Information
Name
Y-27632
FlyBase ID
FBch0000668
ChEBI Name
Y-27632
ChEBI ID
CHEBI:75393
PubChem Name
Y-27632 dihydrochloride
PubChem ID
CID:448042
Chemical Structure
Chemical structure of Y-27632
Y-27632
InChIKey

IYOZTVGMEWJPKR-IJLUTSLNSA-N

IYOZTVGMEWJPKR-VOMCLLRMSA-N

Definition (ChEBI)

ChEBI: Y-27632 is a monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory activity against Rho-associated protein kinase (ROCK) enzyme. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a monocarboxylic acid amide, a member of pyridines and a primary amino compound.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (21)
Synonyms
(R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide
(ChEBI, 2019-)
0X370ROP6H
(PubChem, 2019-)
0x370rop6h
(PubChem, 2019-)
146986-50-7
(PubChem, 2019-)
4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide
(ChEBI, 2019-)
4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
(PubChem, 2019-)
4-[(1r)-1-aminoethyl]-n-pyridin-4-ylcyclohexane-1-carboxamide
(PubChem, 2019-)
CHEBI:75393
(PubChem, 2019-)
Y 27632
(ChEBI, 2019-, PubChem, 2019-)
Y-27632
(Kroeger et al., 2024, Vanderleest et al., 2024, Strilbytska et al., 2020, ChEBI, 2019-, Fan et al., 2019, Kobb et al., 2019, PubChem, 2019-, Segal et al., 2018, Sui et al., 2018, Chung et al., 2017, Fan et al., 2017, Nakamura et al., 2017, Tsankova et al., 2017)
Y-27632 dihydrochloride
(PubChem, 2019-)
Y-27632, free base
(PubChem, 2019-)
Y27632
(PubChem, 2019-, Tsankova et al., 2017)
chebi:75393
(PubChem, 2019-)
cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-
(PubChem, 2019-)
cyclohexanecarboxamide, 4-[(1r)-1-aminoethyl]-n-4-pyridinyl-, trans-
(PubChem, 2019-)
y 27632
(PubChem, 2019-)
y-27632
(PubChem, 2019-)
y-27632 dihydrochloride
(PubChem, 2019-)
y-27632, free base
(PubChem, 2019-)
y27632
(PubChem, 2019-)
Secondary FlyBase IDs
    References (21)