FB2025_01 , released February 20, 2025
Chemical: PJ34
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General Information
Name
PJ34
FlyBase ID
FBch0002092
ChEBI Name
PJ34
ChEBI ID
CHEBI:167900
PubChem Name
N~2~,N~2~-Dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-YL)glycinamide
PubChem ID
CID:4858
Chemical Structure
Chemical structure of PJ34
PJ34
InChIKey

UYJZZVDLGDDTCL-UHFFFAOYSA-N

Definition (ChEBI)

A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (26)
Synonyms
2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
(ChEBI, 2019-, PubChem, 2019-)
2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
(PubChem, 2019-)
2-(dimethylamino)-n-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
(PubChem, 2019-)
2-(dimethylamino)-n-(6-oxo-5h-phenanthridin-2-yl)acetamide
(PubChem, 2019-)
2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one
(ChEBI, 2019-)
344458-19-1
(PubChem, 2019-)
Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-
(PubChem, 2019-)
CHEMBL372303
(PubChem, 2019-)
N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
(ChEBI, 2019-)
N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
(ChEBI, 2019-, PubChem, 2019-)
N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide
(ChEBI, 2019-)
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
(PubChem, 2019-)
P34
(PubChem, 2019-)
PJ 34
(ChEBI, 2019-)
PJ-34
(ChEBI, 2019-)
PJ34
(Russi et al., 2020, ChEBI, 2019-, PubChem, 2019-)
PJ34ssw
(Lee et al., 2024)
PubChem:4858
(PubChem, 2019-)
acetamide, n-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-
(PubChem, 2019-)
chembl372303
(PubChem, 2019-)
n-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
(PubChem, 2019-)
n~2~,n~2~-dimethyl-n~1~-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
(PubChem, 2019-)
p34
(PubChem, 2019-)
pj-34
(PubChem, 2019-)
pj34
(PubChem, 2019-)
pubchem:4858
(PubChem, 2019-)
Secondary FlyBase IDs
    References (4)