FB2025_01 , released February 20, 2025
Gene Group: SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS
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General Information
Name
SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS
Species
D. melanogaster
Symbol
SLC8
FlyBase ID
FBgg0000661
Date last reviewed
2024-06-28
Number of members
6
Description
Description
Solute carrier family 8 (SLC8) members facilitate Ca2+ flux across the plasma membrane by utilizing a counter-Na+ electrochemical gradient. (Adapted from FBrf0216387).
Notes on Group

CG14744 is reported as a SLC24 members in FBrf0214274, but from BLAST analysis and orthology prediction it shows more similarity with the SLC8 family.

Source Material
The SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS Gene Group has been compiled using the following publication(s): Chang et al., 2020, Featherstone, 2011, Wu et al., 2011, and Schwarz and Benzer, 1997 .
Key Gene Ontology (GO) terms
Molecular Function
calcium:sodium antiporter activity
Biological Process
calcium ion homeostasis
Cellular Component
plasma membrane
Related Gene Groups
Parent group(s)
TRANSMEMBRANE CARRIER PROTEINS
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Calx
Na/Ca-exchange protein
NCX, Dmel/Ncx
(Chang et al., 2020, Wu et al., 2011, Schwarz and Benzer, 1997)
CG5348
(Chang et al., 2020)
CG12376
(Chang et al., 2020)
CG13223
(Chang et al., 2020)
CG14743
(Chang et al., 2020)
CG14744
(Chang et al., 2020, Featherstone, 2011)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SLC8
Na+/Ca2+ exchanger
sodium/calcium exchangers
NCX
SLC8 FAMILY OF SODIUM/CALCIUM EXCHANGERS
SOLUTE CARRIER FAMILY 8
Secondary FlyBase ID(s)
References (5)