FlyBase Gene Report: Dsub\Xdh

General Information

Symbol

Dsub\Xdh

Species

D. subobscura

Name

Xanthine dehydrogenase

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013892

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). (UniProt, P91711)

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All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

Xdh

Summaries

Protein Function (UniProtKB)

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).

(UniProt, P91711)

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dsub\Xdh

Transgenic constructs containing regulatory region of Dsub\Xdh

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal eye color

Dsub\Xdh⁰

visible | recessive

Dsub\Xdh⁰

Phenotype manifest in

Allele

pigment cell

Dsub\Xdh⁰

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P91711 )

Linkouts

Class of Gene

gene

protein_coding_gene

(FlyBase curators, 2018-)

Stocks and Reagents

Stocks (0)

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster.

(Segarra et al., 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Dsub\Xdh

XDH

(Bondinas et al., 2002, Bondinas et al., 2001, Pitts and Zwiebel, 2001, Moya et al., 1993)

Xdh

(Rodriguez-Trelles, 2003, Tarrio et al., 2003, Rodriguez-Trelles et al., 2001, Segarra et al., 1996)

Xdh/ry

(Comeron and Kreitman, 1998)

(Dunn et al., 2001)

Name Synonyms

Xanthine dehydrogenase

xanthine dehydrogenas

(Rodriguez-Trelles, 2003)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P91711

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

O96441

Other crossreferences

InterPro - A database of protein families, domains and functional sites

References (28)

Report Sections