FB2025_01 , released February 20, 2025
Gene: Dpse\Sry-alpha
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Important message

Updated sequence information for this Drosophila species is no longer provided by FlyBase. Gene model annotations for this species are now updated and maintained at NCBI, using the gnomon automated annotation pipeline. See the NCBI page ‘Eukaryotic genomes annotated at NCBI’.

The FlyBase BLAST tool will continue to support queries against the reference genome of this species, but not queries against annotated transcripts or proteins. For the current release, there is no JBrowse or GBrowse view of the gene model annotations for this species.

The FlyBase archived release FB2017_05 includes the last NCBI annotation update for this species that was imported into FlyBase. That sequence data can be accessed from archived gene reports, via the archived GBrowse tool, and via archived bulk-data downloads.

General Information
Symbol
Dpse\Sry-alpha
Species
D. pseudoobscura pseudoobscura
Name
Annotation Symbol
Feature Type
protein_coding_gene
FlyBase ID
FBgn0243553
Gene Model Status
Withdrawn
Stock Availability
None publicly available
Gene Summary
Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions (By similarity). (UniProt, Q07964)
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All Summaries
Also Known As

Sry-alpha, sryα

Summaries
Protein Function (UniProtKB)
Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions (By similarity).
(UniProt, Q07964)
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dpse\Sry-alpha
Transgenic constructs containing regulatory region of Dpse\Sry-alpha
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Summary of Genetic Interactions
    esyN Network Diagram
    Other Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Stocks (0)
    Genomic Clones (0)
     
      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    The frequency distribution of "silent" DNA polymorphisms has been studied in a number of D.simulans and D.pseudoobscura.pseudoobscura genes.

                    (Akashi and Schaeffer, 1997)

                    The molecular organization of the 'rp49-Sry-jan' gene cluster, including gene order, direction of transcription and partial overlap of the janA and janB genes is strictly conserved between D.melanogaster and D.pseudoobscura.pseudoobscura.

                    (Yanicostas et al., 1995)

                    The structure and expression of Sry-α has been compared in D.melanogaster, D.pseudoobscura.pseudoobscura and D.subobscura. Highly conserved and diverged regions are dispersed throughout the protein.

                    (Ibnsouda et al., 1993)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: Dpse\GA14740 Dpse\Sry-α

                    (FlyBase, 1992-)
                    Additional comments

                    Dpse\Sry-α can rescue defects in D.melanogaster Sry-α deletion mutants (Df(3R)X3F), even though the two RNAs have different subcellular distributions.

                    (Ibnsouda et al., 1993)
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (10)
                    Reported As
                    Symbol Synonym
                    Dpse\GA14740
                    Dpse\Sry-alpha
                    (Drosophila 12 Genomes Consortium, 2008)
                    GA14740
                    Sry-alpha
                    (Drosophila 12 Genomes Consortium, 2008, Akashi and Schaeffer, 1997, Moriyama and Powell, 1997)
                    dpse_GLEANR_4816
                    (Drosophila 12 Genomes Consortium, 2008)
                    sry alpha
                    (Ibnsouda, 1993)
                    sry-a
                    (Bartolome and Charlesworth, 2006)
                    sry-alpha
                    (Bartolome et al., 2005)
                    sryα
                    (Ibnsouda et al., 1995, Ferrer et al., 1994)
                    Name Synonyms
                    Serendipity α
                    Secondary FlyBase IDs
                    • FBgn0074767
                    • FBgn0012713
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 7 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    Other crossreferences
                    GNOMON -
                    • Dpse_gnomon_102_gene.19750352
                    InterPro - A database of protein families, domains and functional sites
                    References (19)