|Citation||Spring, J. (2000.5.4). FlyBase error report for CG10497 on Thu May 4 05:27:21 2000. (Export to RIS)|
|Publication Type||Personal communication to FlyBase|
|Text of Personal Communication||
From FlyBase-error@XXXXXXXXXXXXXXX Thu May 04 13:22:37 2000
Delivery-date: Thu, 4 May 2000 13:22:37 \+0100
Date: Thu, 4 May 2000 05:27:21 \-0700 (PDT)
X-Authentication-Warning: hedgehog.lbl.gov: web set sender to FlyBase-error
Subject: FlyBase error report
Error report from J. Spring (J.Spring@XXXXXXXXXXXXXXX)
Gene or accession: CG10497
Gene annotation error
Gene CG10497 has incorrect exon/intron structure.
Comments: /gene='Sdc' AE003454 CT27296 CG10497 AAF46724 gi:7291294
The 85 aa Sdc gene product (gi:7291294) does not make sense. With few splice
changes the genomic data
can be adjusted to the published full length cDNA sequence and to 15 ests, so
that a 399 aa protein
product that is similar to other syndecan (Sdc) family members. The chages are
marked with asterisks;
the first (23078 instead of 23080) leads to a frame shift, the second is in
the 5'untranslated and
the last corresponds to the 5' end of the longest cDNA clone (U03282) and do
not affect the protein.
The new product of 299 aa still differs at 3 places from the published protein
of 295 aa (sw:sdc_drome).
But these changes are in repetitive regions and could be polymorphisms. Only
the short cytoplasmic
domain of syndecans is highly conserved (which is now missing in gi:7291294).
against recombinant protein also confirmed a larger protein than 85 aa (Spring
et al. 1994).
In a mRNA spliced according to the following corrected numbers:
the coding sequence would be:
Spring J, Paine-Saunders SE, Hynes RO, Bernfield M.
Drosophila syndecan: conservation of a cell-surface heparan sulfate
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3334-8.
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|Language of Publication||English|
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